Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver

In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not compl...

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Detalles Bibliográficos
Autores principales: Malara, Alessandro, Abbonante, Vittorio, Zingariello, Maria, Migliaccio, Annarita, Balduini, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223581/
https://www.ncbi.nlm.nih.gov/pubmed/30416700
http://dx.doi.org/10.4084/MJHID.2018.068
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author Malara, Alessandro
Abbonante, Vittorio
Zingariello, Maria
Migliaccio, Annarita
Balduini, Alessandra
author_facet Malara, Alessandro
Abbonante, Vittorio
Zingariello, Maria
Migliaccio, Annarita
Balduini, Alessandra
author_sort Malara, Alessandro
collection PubMed
description In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis.
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spelling pubmed-62235812018-11-09 Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver Malara, Alessandro Abbonante, Vittorio Zingariello, Maria Migliaccio, Annarita Balduini, Alessandra Mediterr J Hematol Infect Dis Review Article In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis. Università Cattolica del Sacro Cuore 2018-11-01 /pmc/articles/PMC6223581/ /pubmed/30416700 http://dx.doi.org/10.4084/MJHID.2018.068 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Malara, Alessandro
Abbonante, Vittorio
Zingariello, Maria
Migliaccio, Annarita
Balduini, Alessandra
Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver
title Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver
title_full Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver
title_fullStr Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver
title_full_unstemmed Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver
title_short Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver
title_sort megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223581/
https://www.ncbi.nlm.nih.gov/pubmed/30416700
http://dx.doi.org/10.4084/MJHID.2018.068
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