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Consensus document on the progression and treatment response criteria in gastroenteropancreatic neuroendocrine tumors

PURPOSE: Gastroenteropancreatic neuroendocrine tumors are a heterogeneous group of low incidence neoplasms characterized by a low proliferative activity and slow growth. Their response to targeted therapies is heterogeneous and often does not lead to tumor shrinkage. Thus, evaluation of the therapeu...

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Detalles Bibliográficos
Autores principales: Merino-Casabiel, X., Aller, J., Arbizu, J., García-Figueiras, R., González, C., Grande, E., Jiménez-Fonseca, P., Sevilla, M. I., Capdevila, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223716/
https://www.ncbi.nlm.nih.gov/pubmed/29766455
http://dx.doi.org/10.1007/s12094-018-1881-9
Descripción
Sumario:PURPOSE: Gastroenteropancreatic neuroendocrine tumors are a heterogeneous group of low incidence neoplasms characterized by a low proliferative activity and slow growth. Their response to targeted therapies is heterogeneous and often does not lead to tumor shrinkage. Thus, evaluation of the therapeutic response should differ from other kind of tumors. METHODS: To answer relevant questions about which techniques are best in the assessment of progression or treatment response a RAND/UCLA-based consensus process was implemented. Relevant clinical questions were listed followed by a systematic search of the literature. The expert panel answered all questions with recommendations, combining available evidence and expert opinion. Recommendations were validated through a questionnaire and a participatory meeting. RESULTS: Expert recommendations regarding imaging tools for tumor assessment and evaluation of progression were agreed upon. Available imaging techniques were reviewed and recommendations for best patient monitoring practice and the best way to evaluate treatment response were formulated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12094-018-1881-9) contains supplementary material, which is available to authorized users.