Cargando…
Age-related changes in skeletal muscle: changes to life-style as a therapy
As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. The mecha...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223729/ https://www.ncbi.nlm.nih.gov/pubmed/30259289 http://dx.doi.org/10.1007/s10522-018-9775-3 |
_version_ | 1783369454740045824 |
---|---|
author | McCormick, Rachel Vasilaki, Aphrodite |
author_facet | McCormick, Rachel Vasilaki, Aphrodite |
author_sort | McCormick, Rachel |
collection | PubMed |
description | As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. The mechanisms behind sarcopenia are unclear and it is likely that it is a multifactorial condition with changes in numerous important mechanisms all contributing to the structural and functional deterioration. Here, we review the major proposed changes which occur in skeletal muscle during ageing and highlight evidence for changes in physical activity and nutrition as therapeutic approaches to combat age-related skeletal muscle wasting. |
format | Online Article Text |
id | pubmed-6223729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-62237292018-11-18 Age-related changes in skeletal muscle: changes to life-style as a therapy McCormick, Rachel Vasilaki, Aphrodite Biogerontology Review Article As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. The mechanisms behind sarcopenia are unclear and it is likely that it is a multifactorial condition with changes in numerous important mechanisms all contributing to the structural and functional deterioration. Here, we review the major proposed changes which occur in skeletal muscle during ageing and highlight evidence for changes in physical activity and nutrition as therapeutic approaches to combat age-related skeletal muscle wasting. Springer Netherlands 2018-09-27 2018 /pmc/articles/PMC6223729/ /pubmed/30259289 http://dx.doi.org/10.1007/s10522-018-9775-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Article McCormick, Rachel Vasilaki, Aphrodite Age-related changes in skeletal muscle: changes to life-style as a therapy |
title | Age-related changes in skeletal muscle: changes to life-style as a therapy |
title_full | Age-related changes in skeletal muscle: changes to life-style as a therapy |
title_fullStr | Age-related changes in skeletal muscle: changes to life-style as a therapy |
title_full_unstemmed | Age-related changes in skeletal muscle: changes to life-style as a therapy |
title_short | Age-related changes in skeletal muscle: changes to life-style as a therapy |
title_sort | age-related changes in skeletal muscle: changes to life-style as a therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223729/ https://www.ncbi.nlm.nih.gov/pubmed/30259289 http://dx.doi.org/10.1007/s10522-018-9775-3 |
work_keys_str_mv | AT mccormickrachel agerelatedchangesinskeletalmusclechangestolifestyleasatherapy AT vasilakiaphrodite agerelatedchangesinskeletalmusclechangestolifestyleasatherapy |