Intervertebral Disc Biology: Genetic Basis of Disc Degeneration

PURPOSE OF REVIEW: This review aims to highlight recent advances in understanding the genetic basis of intervertebral disc degeneration (IDD). RECENT FINDINGS: It has been known for some time that IDD is highly heritable. Recent studies, and in particular the availability of agnostic techniques such...

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Autores principales: Munir, Sabrina, Rade, Marinko, Määttä, Juhani H., Freidin, Maxim B., Williams, Frances M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Intervertebral Disk Degeneration and Regeneration (MV Risbud, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223888/
https://www.ncbi.nlm.nih.gov/pubmed/30464887
http://dx.doi.org/10.1007/s40610-018-0101-2
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author Munir, Sabrina
Rade, Marinko
Määttä, Juhani H.
Freidin, Maxim B.
Williams, Frances M. K.
author_facet Munir, Sabrina
Rade, Marinko
Määttä, Juhani H.
Freidin, Maxim B.
Williams, Frances M. K.
author_sort Munir, Sabrina
collection PubMed
description PURPOSE OF REVIEW: This review aims to highlight recent advances in understanding the genetic basis of intervertebral disc degeneration (IDD). RECENT FINDINGS: It has been known for some time that IDD is highly heritable. Recent studies, and in particular the availability of agnostic techniques such as genome-wide association studies, have identified new variants in a variety of genes which contribute to the risk of IDD and to back pain. SUMMARY: A variety of genetic variants are involved in IDD. Some are shared with variants predisposing to back pain, but few have been identified reliably in either phenotype. Further research is required to explain fully the high heritability and how the genetic variants influence cell biology to lead to IDD.
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spelling pubmed-62238882018-11-19 Intervertebral Disc Biology: Genetic Basis of Disc Degeneration Munir, Sabrina Rade, Marinko Määttä, Juhani H. Freidin, Maxim B. Williams, Frances M. K. Curr Mol Biol Rep Intervertebral Disk Degeneration and Regeneration (MV Risbud, Section Editor) PURPOSE OF REVIEW: This review aims to highlight recent advances in understanding the genetic basis of intervertebral disc degeneration (IDD). RECENT FINDINGS: It has been known for some time that IDD is highly heritable. Recent studies, and in particular the availability of agnostic techniques such as genome-wide association studies, have identified new variants in a variety of genes which contribute to the risk of IDD and to back pain. SUMMARY: A variety of genetic variants are involved in IDD. Some are shared with variants predisposing to back pain, but few have been identified reliably in either phenotype. Further research is required to explain fully the high heritability and how the genetic variants influence cell biology to lead to IDD. Springer International Publishing 2018-08-03 2018 /pmc/articles/PMC6223888/ /pubmed/30464887 http://dx.doi.org/10.1007/s40610-018-0101-2 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Intervertebral Disk Degeneration and Regeneration (MV Risbud, Section Editor)
Munir, Sabrina
Rade, Marinko
Määttä, Juhani H.
Freidin, Maxim B.
Williams, Frances M. K.
Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
title Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
title_full Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
title_fullStr Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
title_full_unstemmed Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
title_short Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
title_sort intervertebral disc biology: genetic basis of disc degeneration
topic Intervertebral Disk Degeneration and Regeneration (MV Risbud, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223888/
https://www.ncbi.nlm.nih.gov/pubmed/30464887
http://dx.doi.org/10.1007/s40610-018-0101-2
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