Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography

Chagas disease, caused by Trypanosoma cruzi, affects millions of people in South America and no satisfactory therapy exists, especially for its life threatening chronic phase. We targeted the Proline Racemase of T. cruzi, which is present in all stages of the parasite life cycle, to discover new inh...

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Detalles Bibliográficos
Autores principales: Amaral, Patricia de Aguiar, Autheman, Delphine, de Melo, Guilherme Dias, Gouault, Nicolas, Cupif, Jean-François, Goyard, Sophie, Dutra, Patricia, Coatnoan, Nicolas, Cosson, Alain, Monet, Damien, Saul, Frederick, Haouz, Ahmed, Uriac, Philippe, Blondel, Arnaud, Minoprio, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224121/
https://www.ncbi.nlm.nih.gov/pubmed/30372428
http://dx.doi.org/10.1371/journal.pntd.0006853

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