Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

Antisense oligonucleotides (ASOs) have demonstrated variation of efficacy in patient populations. This has prompted our investigation into the contribution of genetic architecture to ASO pharmacokinetics (PK) and pharmacodynamics (PD). Genome wide association (GWA) and transcriptomic analysis in a h...

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Detalles Bibliográficos
Autores principales: Pirie, Elaine, Ray, Shayoni, Pan, Calvin, Fu, Wuxia, Powers, Andrew F., Polikoff, Danielle, Miller, Colton M., Kudrna, Katrina M., Harris, Edward N., Lusis, Aldons J., Crooke, Rosanne M., Lee, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224167/
https://www.ncbi.nlm.nih.gov/pubmed/30372444
http://dx.doi.org/10.1371/journal.pgen.1007732

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