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Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?

Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests tha...

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Detalles Bibliográficos
Autores principales: Dazzan, Paola, Fusté, Montserrat, Davies, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224363/
https://www.ncbi.nlm.nih.gov/pubmed/30348609
http://dx.doi.org/10.1016/j.molmed.2018.09.002
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author Dazzan, Paola
Fusté, Montserrat
Davies, William
author_facet Dazzan, Paola
Fusté, Montserrat
Davies, William
author_sort Dazzan, Paola
collection PubMed
description Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests that immune system (dys)function plays an important role in disorder onset. On the basis of new findings from clinical and animal model studies, we hypothesise that the abundance and/or activity of regulatory T cells, and the efficacy of consequent (re)myelination processes in the brain mediated by CCN proteins, is perturbed in PP; this pathway may be modulated by risk and protective/treatment factors for the disorder, and identifying abnormalities within it could signpost novel predictive biomarkers and therapeutic targets.
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spelling pubmed-62243632018-11-13 Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? Dazzan, Paola Fusté, Montserrat Davies, William Trends Mol Med Article Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests that immune system (dys)function plays an important role in disorder onset. On the basis of new findings from clinical and animal model studies, we hypothesise that the abundance and/or activity of regulatory T cells, and the efficacy of consequent (re)myelination processes in the brain mediated by CCN proteins, is perturbed in PP; this pathway may be modulated by risk and protective/treatment factors for the disorder, and identifying abnormalities within it could signpost novel predictive biomarkers and therapeutic targets. Elsevier Science Ltd 2018-11 /pmc/articles/PMC6224363/ /pubmed/30348609 http://dx.doi.org/10.1016/j.molmed.2018.09.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dazzan, Paola
Fusté, Montserrat
Davies, William
Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?
title Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?
title_full Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?
title_fullStr Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?
title_full_unstemmed Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?
title_short Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?
title_sort do defective immune system-mediated myelination processes increase postpartum psychosis risk?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224363/
https://www.ncbi.nlm.nih.gov/pubmed/30348609
http://dx.doi.org/10.1016/j.molmed.2018.09.002
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