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Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?
Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests tha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224363/ https://www.ncbi.nlm.nih.gov/pubmed/30348609 http://dx.doi.org/10.1016/j.molmed.2018.09.002 |
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author | Dazzan, Paola Fusté, Montserrat Davies, William |
author_facet | Dazzan, Paola Fusté, Montserrat Davies, William |
author_sort | Dazzan, Paola |
collection | PubMed |
description | Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests that immune system (dys)function plays an important role in disorder onset. On the basis of new findings from clinical and animal model studies, we hypothesise that the abundance and/or activity of regulatory T cells, and the efficacy of consequent (re)myelination processes in the brain mediated by CCN proteins, is perturbed in PP; this pathway may be modulated by risk and protective/treatment factors for the disorder, and identifying abnormalities within it could signpost novel predictive biomarkers and therapeutic targets. |
format | Online Article Text |
id | pubmed-6224363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62243632018-11-13 Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? Dazzan, Paola Fusté, Montserrat Davies, William Trends Mol Med Article Postpartum (or puerperal) psychosis (PP) is a rare, severe psychiatric disorder that affects women shortly after childbirth; risk is particularly high in individuals with a history of bipolar disorder or PP, but the underlying pathophysiology remains poorly understood. Emerging evidence suggests that immune system (dys)function plays an important role in disorder onset. On the basis of new findings from clinical and animal model studies, we hypothesise that the abundance and/or activity of regulatory T cells, and the efficacy of consequent (re)myelination processes in the brain mediated by CCN proteins, is perturbed in PP; this pathway may be modulated by risk and protective/treatment factors for the disorder, and identifying abnormalities within it could signpost novel predictive biomarkers and therapeutic targets. Elsevier Science Ltd 2018-11 /pmc/articles/PMC6224363/ /pubmed/30348609 http://dx.doi.org/10.1016/j.molmed.2018.09.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dazzan, Paola Fusté, Montserrat Davies, William Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? |
title | Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? |
title_full | Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? |
title_fullStr | Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? |
title_full_unstemmed | Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? |
title_short | Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk? |
title_sort | do defective immune system-mediated myelination processes increase postpartum psychosis risk? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224363/ https://www.ncbi.nlm.nih.gov/pubmed/30348609 http://dx.doi.org/10.1016/j.molmed.2018.09.002 |
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