Homotaurine, a safe blood-brain barrier permeable GABA(A)-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis

There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABA(A)-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models. Whether GABA(A)-R agonists can also inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Jide, Dang, Hoa, Wallner, Martin, Olsen, Richard, Kaufman, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224391/
https://www.ncbi.nlm.nih.gov/pubmed/30410049
http://dx.doi.org/10.1038/s41598-018-32733-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224391/
https://www.ncbi.nlm.nih.gov/pubmed/30410049
http://dx.doi.org/10.1038/s41598-018-32733-3

Ejemplares similares