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Homotaurine, a safe blood-brain barrier permeable GABA(A)-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis
There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABA(A)-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models. Whether GABA(A)-R agonists can also inhibit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224391/ https://www.ncbi.nlm.nih.gov/pubmed/30410049 http://dx.doi.org/10.1038/s41598-018-32733-3 |