Cargando…

New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment

The microenvironments of leukemia and cancer are critical for multiple stages of malignancies, and they are an attractive therapeutic target. While skeletal abnormalities are commonly seen in children with acute lymphoblastic leukemia (ALL) prior to initiating osteotoxic therapy, little is known abo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheung, Laurence C., Tickner, Jennifer, Hughes, Anastasia M., Skut, Patrycja, Howlett, Meegan, Foley, Bree, Oommen, Joyce, Wells, Julia E., He, Bo, Singh, Sajla, Chua, Grace-Alyssa, Ford, Jette, Mullighan, Charles G., Kotecha, Rishi S., Kees, Ursula R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224400/ https://www.ncbi.nlm.nih.gov/pubmed/29740160 http://dx.doi.org/10.1038/s41375-018-0144-7

Ejemplares similares

The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution
por: Anderson, Denise, et al.
Publicado: (2020)

Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia
por: Cheung, Laurence C., et al.
Publicado: (2021)

Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma—an aggressive and fatal disease
por: Stirnweiss, Anja, et al.
Publicado: (2017)

Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia
por: Hughes, Anastasia M., et al.
Publicado: (2023)

The Bone Marrow Microenvironment in B-Cell Development and Malignancy
por: Hughes, Anastasia M., et al.
Publicado: (2022)

Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy
por: Cheung, Laurence C., et al.
Publicado: (2022)

Targeting the bone marrow microenvironment: a novel therapeutic strategy for pre-B acute lymphoblastic leukemia
por: Kotecha, Rishi S., et al.
Publicado: (2019)

Therapeutic Targeting of the Leukaemia Microenvironment
por: Kuek, Vincent, et al.
Publicado: (2021)

Rare childhood cancers—an increasing entity requiring the need for global consensus and collaboration
por: Kotecha, Rishi S, et al.
Publicado: (2015)

Case Report: Long-Term Survival of a Pediatric Patient With an Intra-Abdominal Undifferentiated Carcinoma of Unknown Primary
por: Stirnweiss, Anja, et al.
Publicado: (2021)

Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo
por: Judd, Louise M., et al.
Publicado: (2014)

Identifying the optimal donor for natural killer cell adoptive therapy to treat paediatric B‐ and T‐cell acute lymphoblastic leukaemia
por: Foley, Bree, et al.
Publicado: (2020)

Amsacrine Derivatives Selectively Inhibit Mycobacterial Topoisomerase I (TopA), Impair M. smegmatis Growth and Disturb Chromosome Replication
por: Szafran, Marcin J., et al.
Publicado: (2018)

Challenges posed by COVID-19 to children with cancer
por: Kotecha, Rishi S
Publicado: (2020)

Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis
por: Whitehouse, Jacqueline P, et al.
Publicado: (2021)

Marrow relapse on maintenance chemotherapy in childhood acute lymphoblastic leukaemia.
por: Kearney, P. J., et al.
Publicado: (1979)

Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia
por: Beesley, Alex H, et al.
Publicado: (2010)

Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes
por: Espinoza, J. Luis, et al.
Publicado: (2017)

Inter-rater agreement for the annotation of neurologic signs and symptoms in electronic health records
por: Oommen, Chelsea, et al.
Publicado: (2023)

Dysregulated transforming growth factor-beta mediates early bone marrow dysfunction in diabetes
por: Kum, Jina J. Y., et al.
Publicado: (2022)

Subtypes of relapsing-remitting multiple sclerosis identified by network analysis
por: Howlett-Prieto, Quentin, et al.
Publicado: (2023)

Choreography of the Mycobacterium Replication Machinery during the Cell Cycle
por: Trojanowski, Damian, et al.
Publicado: (2015)

The Successful Frauditor's Casebook
por: Tickner, Peter
Publicado: (2012)

RONC-02. MEASURING THE EFFECT OF CLINICALLY-RELEVANT RADIOTHERAPY PROTOCOLS ON THE JUVENILE MOUSE BRAIN
por: Buck, Jessica, et al.
Publicado: (2020)

Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome
por: Laurent, Anouchka P., et al.
Publicado: (2020)

Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
por: Wang, Lipeng, et al.
Publicado: (2021)

A Rare Case of Chronic Small Bowel Pseudo-Obstruction
por: Lim, Joyce, et al.
Publicado: (2020)

Theories Informing eHealth Implementation: Systematic Review and Typology Classification
por: Heinsch, Milena, et al.
Publicado: (2021)

The evolution of clinical trials for infant acute lymphoblastic leukemia
por: Kotecha, R S, et al.
Publicado: (2014)

Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin
por: Cruickshank, M N, et al.
Publicado: (2017)

Blinatumomab as bridging therapy in paediatric B‐cell acute lymphoblastic leukaemia complicated by invasive fungal disease
por: Yeoh, Daniel K., et al.
Publicado: (2022)

The Allergic Bone Marrow? The Immuno-Capacity of the Human Bone Marrow in Context of Metal-Associated Hypersensitivity Reactions
por: Ort, Melanie J., et al.
Publicado: (2019)

Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets
por: Abbas, Zahra, et al.
Publicado: (2022)

Bone Marrow Microenvironment and Tumor Progression
por: Chantrain, Christophe F., et al.
Publicado: (2008)

Targeting the leukemic bone marrow microenvironment
por: von der Heide, Eva Kristin, et al.
Publicado: (2017)

Editorial: NK Cells in Human Diseases: Friends or Foes?
por: Vieillard, Vincent, et al.
Publicado: (2017)

Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity
por: Dolgalev, Igor, et al.
Publicado: (2021)

Correction: Tickner, Z.J.; Farzan, M. Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors. Pharmaceuticals 2021, 14, 554
por: Tickner, Zachary J., et al.
Publicado: (2021)

Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors
por: Tickner, Zachary J., et al.
Publicado: (2021)

Zero-Sum Bias: Perceived Competition Despite Unlimited Resources
por: Meegan, Daniel V.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_9rof3764qkhn4r3ct702uk65eg