The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism

Previous research has suggested that thyroid hormone receptor alpha 1 (THRα1), a hormone responsive splice variant, may play a role in breast cancer progression. Whether THRα1 can be exploited for anti-cancer therapy is unknown. The antiproliferative and antitumor effects of dronedarone, an FDA-appr...

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Detalles Bibliográficos
Autores principales: Elliott, Mitchell J., Jerzak, Katarzyna J., Cockburn, Jessica G., Safikhani, Zhaleh, Gwynne, William D., Hassell, John A., Bane, Anita, Silvester, Jennifer, Thu, Kelsie L., Haibe-Kains, Benjamin, Mak, Tak W., Cescon, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224430/
https://www.ncbi.nlm.nih.gov/pubmed/30410118
http://dx.doi.org/10.1038/s41598-018-34348-0

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