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Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases
Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis dysfunction at the level of the endoplasmic reticulum (ER) are central contributors to neurodegenerative diseases. The unfolded protein respo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224445/ https://www.ncbi.nlm.nih.gov/pubmed/30450103 http://dx.doi.org/10.3389/fimmu.2018.02541 |
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author | García-González, Paulina Cabral-Miranda, Felipe Hetz, Claudio Osorio, Fabiola |
author_facet | García-González, Paulina Cabral-Miranda, Felipe Hetz, Claudio Osorio, Fabiola |
author_sort | García-González, Paulina |
collection | PubMed |
description | Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis dysfunction at the level of the endoplasmic reticulum (ER) are central contributors to neurodegenerative diseases. The unfolded protein response (UPR) is the main transduction pathway that maintains protein homeostasis under conditions of protein misfolding and aggregation. Brain inflammation often coexists with the degenerative process in different brain diseases. Interestingly, besides its well-described role in neuronal fitness, the UPR has also emerged as a key regulator of ontogeny and function of several immune cell types. Nevertheless, the contribution of the UPR to brain inflammation initiated by immune cells remains largely unexplored. In this review, we provide a perspective on the potential role of ER stress signaling in brain-associated immune cells and the possible implications to neuroinflammation and development of neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-6224445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62244452018-11-16 Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases García-González, Paulina Cabral-Miranda, Felipe Hetz, Claudio Osorio, Fabiola Front Immunol Immunology Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis dysfunction at the level of the endoplasmic reticulum (ER) are central contributors to neurodegenerative diseases. The unfolded protein response (UPR) is the main transduction pathway that maintains protein homeostasis under conditions of protein misfolding and aggregation. Brain inflammation often coexists with the degenerative process in different brain diseases. Interestingly, besides its well-described role in neuronal fitness, the UPR has also emerged as a key regulator of ontogeny and function of several immune cell types. Nevertheless, the contribution of the UPR to brain inflammation initiated by immune cells remains largely unexplored. In this review, we provide a perspective on the potential role of ER stress signaling in brain-associated immune cells and the possible implications to neuroinflammation and development of neurodegenerative diseases. Frontiers Media S.A. 2018-11-02 /pmc/articles/PMC6224445/ /pubmed/30450103 http://dx.doi.org/10.3389/fimmu.2018.02541 Text en Copyright © 2018 García-González, Cabral-Miranda, Hetz and Osorio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology García-González, Paulina Cabral-Miranda, Felipe Hetz, Claudio Osorio, Fabiola Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases |
title | Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases |
title_full | Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases |
title_fullStr | Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases |
title_full_unstemmed | Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases |
title_short | Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases |
title_sort | interplay between the unfolded protein response and immune function in the development of neurodegenerative diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224445/ https://www.ncbi.nlm.nih.gov/pubmed/30450103 http://dx.doi.org/10.3389/fimmu.2018.02541 |
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