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Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans

Serotonin is implicated in multiple executive functions including goal-directed learning, cognitive flexibility, response inhibition and emotional regulation. These functions are impaired in several psychiatric disorders, such as depression and obsessive–compulsive disorder. We tested the cognitive...

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Autores principales: Skandali, Nikolina, Rowe, James B., Voon, Valerie, Deakin, Julia B., Cardinal, Rudolf N., Cormack, Francesca, Passamonti, Luca, Bevan-Jones, William R., Regenthal, Ralf, Chamberlain, Samuel R., Robbins, Trevor W., Sahakian, Barbara J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224451/
https://www.ncbi.nlm.nih.gov/pubmed/30305705
http://dx.doi.org/10.1038/s41386-018-0229-z
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author Skandali, Nikolina
Rowe, James B.
Voon, Valerie
Deakin, Julia B.
Cardinal, Rudolf N.
Cormack, Francesca
Passamonti, Luca
Bevan-Jones, William R.
Regenthal, Ralf
Chamberlain, Samuel R.
Robbins, Trevor W.
Sahakian, Barbara J.
author_facet Skandali, Nikolina
Rowe, James B.
Voon, Valerie
Deakin, Julia B.
Cardinal, Rudolf N.
Cormack, Francesca
Passamonti, Luca
Bevan-Jones, William R.
Regenthal, Ralf
Chamberlain, Samuel R.
Robbins, Trevor W.
Sahakian, Barbara J.
author_sort Skandali, Nikolina
collection PubMed
description Serotonin is implicated in multiple executive functions including goal-directed learning, cognitive flexibility, response inhibition and emotional regulation. These functions are impaired in several psychiatric disorders, such as depression and obsessive–compulsive disorder. We tested the cognitive effects of the selective serotonin reuptake inhibitor escitalopram, using an acute and clinically relevant dose (20 mg), in 66 healthy male and female volunteers in a double-blind, placebo-controlled study. Participants performed a cognitive test battery including a probabilistic and reversal learning task, the CANTAB intra-dimensional/extra-dimensional shift test of cognitive flexibility, a response inhibition task with interleaved stop-signal and No-Go trials and tasks measuring emotional processing. We showed that acute escitalopram administration impaired learning and cognitive flexibility, but improved the ability to inhibit responses in stop-signal trials while leaving unaffected acute emotional processing. Our findings suggest a dissociation of effects of acute escitalopram on cognitive functions, possibly mediated by differential modulation of brain serotonin levels in distinct functional neural circuits.
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spelling pubmed-62244512018-11-13 Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans Skandali, Nikolina Rowe, James B. Voon, Valerie Deakin, Julia B. Cardinal, Rudolf N. Cormack, Francesca Passamonti, Luca Bevan-Jones, William R. Regenthal, Ralf Chamberlain, Samuel R. Robbins, Trevor W. Sahakian, Barbara J. Neuropsychopharmacology Article Serotonin is implicated in multiple executive functions including goal-directed learning, cognitive flexibility, response inhibition and emotional regulation. These functions are impaired in several psychiatric disorders, such as depression and obsessive–compulsive disorder. We tested the cognitive effects of the selective serotonin reuptake inhibitor escitalopram, using an acute and clinically relevant dose (20 mg), in 66 healthy male and female volunteers in a double-blind, placebo-controlled study. Participants performed a cognitive test battery including a probabilistic and reversal learning task, the CANTAB intra-dimensional/extra-dimensional shift test of cognitive flexibility, a response inhibition task with interleaved stop-signal and No-Go trials and tasks measuring emotional processing. We showed that acute escitalopram administration impaired learning and cognitive flexibility, but improved the ability to inhibit responses in stop-signal trials while leaving unaffected acute emotional processing. Our findings suggest a dissociation of effects of acute escitalopram on cognitive functions, possibly mediated by differential modulation of brain serotonin levels in distinct functional neural circuits. Springer International Publishing 2018-09-26 2018-12 /pmc/articles/PMC6224451/ /pubmed/30305705 http://dx.doi.org/10.1038/s41386-018-0229-z Text en © American College of Neuropsychopharmacology 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Skandali, Nikolina
Rowe, James B.
Voon, Valerie
Deakin, Julia B.
Cardinal, Rudolf N.
Cormack, Francesca
Passamonti, Luca
Bevan-Jones, William R.
Regenthal, Ralf
Chamberlain, Samuel R.
Robbins, Trevor W.
Sahakian, Barbara J.
Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans
title Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans
title_full Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans
title_fullStr Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans
title_full_unstemmed Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans
title_short Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans
title_sort dissociable effects of acute ssri (escitalopram) on executive, learning and emotional functions in healthy humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224451/
https://www.ncbi.nlm.nih.gov/pubmed/30305705
http://dx.doi.org/10.1038/s41386-018-0229-z
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