ZNF598 Is a Quality Control Sensor of Collided Ribosomes

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and ubiquitinates stalled ribosomes selectively is unclear. Here, we find that the minimal unit engaged by ZNF598 is the c...

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Detalles Bibliográficos
Autores principales: Juszkiewicz, Szymon, Chandrasekaran, Viswanathan, Lin, Zhewang, Kraatz, Sebastian, Ramakrishnan, V., Hegde, Ramanujan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224477/
https://www.ncbi.nlm.nih.gov/pubmed/30293783
http://dx.doi.org/10.1016/j.molcel.2018.08.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224477/
https://www.ncbi.nlm.nih.gov/pubmed/30293783
http://dx.doi.org/10.1016/j.molcel.2018.08.037

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