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Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide

Glioblastoma (GBM) is a malignant, primary brain tumor, highly resistant to conventional therapies. Temozolomide (TMZ) is a first line therapeutic agent in GBM patients, however, survival of such patients is poor. High level of DNA repair protein, O(6)-methylguanine-DNA-methyltransferase (MGMT) and...

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Detalles Bibliográficos
Autores principales:	Ciechomska, Iwona Anna, Marciniak, Marta Patrycja, Jackl, Judyta, Kaminska, Bozena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224489/ https://www.ncbi.nlm.nih.gov/pubmed/30450051 http://dx.doi.org/10.3389/fphar.2018.01271

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