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Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs
To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided bone regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently or in combination, for repair of alveolar bone defects in Beagle dogs. Six months after extraction of the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224530/ https://www.ncbi.nlm.nih.gov/pubmed/30410063 http://dx.doi.org/10.1038/s41598-018-34805-w |
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author | Li, HuiPing Zheng, JiSi Zhang, Shanyong Yang, Chi Kwon, Yong-Dae Kim, Yong-Jin |
author_facet | Li, HuiPing Zheng, JiSi Zhang, Shanyong Yang, Chi Kwon, Yong-Dae Kim, Yong-Jin |
author_sort | Li, HuiPing |
collection | PubMed |
description | To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided bone regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently or in combination, for repair of alveolar bone defects in Beagle dogs. Six months after extraction of the mandibular premolars and first molars from three beagle dogs, we inserted implants assigned into 3 groups and covered with the following membrane combinations: Group A: Implant + Bio-Oss + Ti-mesh, Group B: Implant + Bio-Oss + Bio-Gide, and Group C: Implant + Bio-Oss + Ti-mesh + Bio-Gide. At 6 months, micro-CT revealed that bone volume/total volume (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th) was significantly greater in Group C than the other two groups, while trabecular separation (Tb.Sp) was significantly lower, suggesting improved bone regeneration. The distance between bands of three fluorescent tracking dyes was significantly greater in Group C, indicating faster deposition of new bone. The Bio-Oss particles were ideally integrated with newly deposited bone and bone thickness was significantly larger in Group C. These findings suggest that combination of Bio-Gide membrane and titanium mesh can effectively repair peri-implant alveolar bone defects, achieving enhanced bone regeneration compared to titanium mesh or Bio-Gide alone, and therefore providing a novel treatment concept for clinical implant surgery. |
format | Online Article Text |
id | pubmed-6224530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62245302018-11-13 Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs Li, HuiPing Zheng, JiSi Zhang, Shanyong Yang, Chi Kwon, Yong-Dae Kim, Yong-Jin Sci Rep Article To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided bone regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently or in combination, for repair of alveolar bone defects in Beagle dogs. Six months after extraction of the mandibular premolars and first molars from three beagle dogs, we inserted implants assigned into 3 groups and covered with the following membrane combinations: Group A: Implant + Bio-Oss + Ti-mesh, Group B: Implant + Bio-Oss + Bio-Gide, and Group C: Implant + Bio-Oss + Ti-mesh + Bio-Gide. At 6 months, micro-CT revealed that bone volume/total volume (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th) was significantly greater in Group C than the other two groups, while trabecular separation (Tb.Sp) was significantly lower, suggesting improved bone regeneration. The distance between bands of three fluorescent tracking dyes was significantly greater in Group C, indicating faster deposition of new bone. The Bio-Oss particles were ideally integrated with newly deposited bone and bone thickness was significantly larger in Group C. These findings suggest that combination of Bio-Gide membrane and titanium mesh can effectively repair peri-implant alveolar bone defects, achieving enhanced bone regeneration compared to titanium mesh or Bio-Gide alone, and therefore providing a novel treatment concept for clinical implant surgery. Nature Publishing Group UK 2018-11-08 /pmc/articles/PMC6224530/ /pubmed/30410063 http://dx.doi.org/10.1038/s41598-018-34805-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Li, HuiPing Zheng, JiSi Zhang, Shanyong Yang, Chi Kwon, Yong-Dae Kim, Yong-Jin Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs |
title | Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs |
title_full | Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs |
title_fullStr | Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs |
title_full_unstemmed | Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs |
title_short | Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs |
title_sort | experiment of gbr for repair of peri-implant alveolar defects in beagle dogs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224530/ https://www.ncbi.nlm.nih.gov/pubmed/30410063 http://dx.doi.org/10.1038/s41598-018-34805-w |
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