Cargando…

Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs

To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided bone regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently or in combination, for repair of alveolar bone defects in Beagle dogs. Six months after extraction of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, HuiPing, Zheng, JiSi, Zhang, Shanyong, Yang, Chi, Kwon, Yong-Dae, Kim, Yong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224530/
https://www.ncbi.nlm.nih.gov/pubmed/30410063
http://dx.doi.org/10.1038/s41598-018-34805-w
_version_ 1783369617526226944
author Li, HuiPing
Zheng, JiSi
Zhang, Shanyong
Yang, Chi
Kwon, Yong-Dae
Kim, Yong-Jin
author_facet Li, HuiPing
Zheng, JiSi
Zhang, Shanyong
Yang, Chi
Kwon, Yong-Dae
Kim, Yong-Jin
author_sort Li, HuiPing
collection PubMed
description To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided bone regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently or in combination, for repair of alveolar bone defects in Beagle dogs. Six months after extraction of the mandibular premolars and first molars from three beagle dogs, we inserted implants assigned into 3 groups and covered with the following membrane combinations: Group A: Implant + Bio-Oss + Ti-mesh, Group B: Implant + Bio-Oss + Bio-Gide, and Group C: Implant + Bio-Oss + Ti-mesh + Bio-Gide. At 6 months, micro-CT revealed that bone volume/total volume (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th) was significantly greater in Group C than the other two groups, while trabecular separation (Tb.Sp) was significantly lower, suggesting improved bone regeneration. The distance between bands of three fluorescent tracking dyes was significantly greater in Group C, indicating faster deposition of new bone. The Bio-Oss particles were ideally integrated with newly deposited bone and bone thickness was significantly larger in Group C. These findings suggest that combination of Bio-Gide membrane and titanium mesh can effectively repair peri-implant alveolar bone defects, achieving enhanced bone regeneration compared to titanium mesh or Bio-Gide alone, and therefore providing a novel treatment concept for clinical implant surgery.
format Online
Article
Text
id pubmed-6224530
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-62245302018-11-13 Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs Li, HuiPing Zheng, JiSi Zhang, Shanyong Yang, Chi Kwon, Yong-Dae Kim, Yong-Jin Sci Rep Article To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided bone regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently or in combination, for repair of alveolar bone defects in Beagle dogs. Six months after extraction of the mandibular premolars and first molars from three beagle dogs, we inserted implants assigned into 3 groups and covered with the following membrane combinations: Group A: Implant + Bio-Oss + Ti-mesh, Group B: Implant + Bio-Oss + Bio-Gide, and Group C: Implant + Bio-Oss + Ti-mesh + Bio-Gide. At 6 months, micro-CT revealed that bone volume/total volume (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th) was significantly greater in Group C than the other two groups, while trabecular separation (Tb.Sp) was significantly lower, suggesting improved bone regeneration. The distance between bands of three fluorescent tracking dyes was significantly greater in Group C, indicating faster deposition of new bone. The Bio-Oss particles were ideally integrated with newly deposited bone and bone thickness was significantly larger in Group C. These findings suggest that combination of Bio-Gide membrane and titanium mesh can effectively repair peri-implant alveolar bone defects, achieving enhanced bone regeneration compared to titanium mesh or Bio-Gide alone, and therefore providing a novel treatment concept for clinical implant surgery. Nature Publishing Group UK 2018-11-08 /pmc/articles/PMC6224530/ /pubmed/30410063 http://dx.doi.org/10.1038/s41598-018-34805-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, HuiPing
Zheng, JiSi
Zhang, Shanyong
Yang, Chi
Kwon, Yong-Dae
Kim, Yong-Jin
Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs
title Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs
title_full Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs
title_fullStr Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs
title_full_unstemmed Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs
title_short Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs
title_sort experiment of gbr for repair of peri-implant alveolar defects in beagle dogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224530/
https://www.ncbi.nlm.nih.gov/pubmed/30410063
http://dx.doi.org/10.1038/s41598-018-34805-w
work_keys_str_mv AT lihuiping experimentofgbrforrepairofperiimplantalveolardefectsinbeagledogs
AT zhengjisi experimentofgbrforrepairofperiimplantalveolardefectsinbeagledogs
AT zhangshanyong experimentofgbrforrepairofperiimplantalveolardefectsinbeagledogs
AT yangchi experimentofgbrforrepairofperiimplantalveolardefectsinbeagledogs
AT kwonyongdae experimentofgbrforrepairofperiimplantalveolardefectsinbeagledogs
AT kimyongjin experimentofgbrforrepairofperiimplantalveolardefectsinbeagledogs