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PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age

Opioid receptors are implicated in alcoholism, other addictions, withdrawal, and depression, and are considered potential pharmacological targets for treatment. Our goal in the present study was to compare the availability of kappa opioid receptors (KOR) between an alcohol-dependent cohort (AD) and...

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Autores principales: Vijay, Aishwarya, Cavallo, Dana, Goldberg, Alissa, de Laat, Bart, Nabulsi, Nabeel, Huang, Yiyun, Krishnan-Sarin, Suchitra, Morris, Evan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224533/
https://www.ncbi.nlm.nih.gov/pubmed/30188515
http://dx.doi.org/10.1038/s41386-018-0199-1
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author Vijay, Aishwarya
Cavallo, Dana
Goldberg, Alissa
de Laat, Bart
Nabulsi, Nabeel
Huang, Yiyun
Krishnan-Sarin, Suchitra
Morris, Evan D.
author_facet Vijay, Aishwarya
Cavallo, Dana
Goldberg, Alissa
de Laat, Bart
Nabulsi, Nabeel
Huang, Yiyun
Krishnan-Sarin, Suchitra
Morris, Evan D.
author_sort Vijay, Aishwarya
collection PubMed
description Opioid receptors are implicated in alcoholism, other addictions, withdrawal, and depression, and are considered potential pharmacological targets for treatment. Our goal in the present study was to compare the availability of kappa opioid receptors (KOR) between an alcohol-dependent cohort (AD) and a healthy control cohort (HC). Sixty-four participants—36 AD and 28 HC—underwent PET scans with [(11)C]LY2795050, a selective kappa antagonist tracer. Partial-volume correction was applied to all PET data to correct for atrophy. Volume of distribution (V(T)) of the tracer was estimated regionally as a measure of KOR availability. V(T) values of AD versus HC were compared for 15 defined ROIs. Multivariate analysis showed a main effect of group on V(T) across these 15 ROIs. Post hoc tests showed that AD had significantly lower V(T) and thus a lower KOR availability than HC in amygdala and pallidum (corrected for multiple comparisons). Exploratory analysis of change in V(T) with age was conducted; V(T) was not found to vary significantly with age in any region. Our findings of lower V(T) in AD versus HC in multiple regions are in contrast to findings in the mu and delta opioid receptor systems of higher V(T) in AD versus HC. Although age-related decline in receptors has previously been observed in the mu opioid receptor system, we found that KOR availability does not change with age.
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spelling pubmed-62245332018-11-13 PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age Vijay, Aishwarya Cavallo, Dana Goldberg, Alissa de Laat, Bart Nabulsi, Nabeel Huang, Yiyun Krishnan-Sarin, Suchitra Morris, Evan D. Neuropsychopharmacology Article Opioid receptors are implicated in alcoholism, other addictions, withdrawal, and depression, and are considered potential pharmacological targets for treatment. Our goal in the present study was to compare the availability of kappa opioid receptors (KOR) between an alcohol-dependent cohort (AD) and a healthy control cohort (HC). Sixty-four participants—36 AD and 28 HC—underwent PET scans with [(11)C]LY2795050, a selective kappa antagonist tracer. Partial-volume correction was applied to all PET data to correct for atrophy. Volume of distribution (V(T)) of the tracer was estimated regionally as a measure of KOR availability. V(T) values of AD versus HC were compared for 15 defined ROIs. Multivariate analysis showed a main effect of group on V(T) across these 15 ROIs. Post hoc tests showed that AD had significantly lower V(T) and thus a lower KOR availability than HC in amygdala and pallidum (corrected for multiple comparisons). Exploratory analysis of change in V(T) with age was conducted; V(T) was not found to vary significantly with age in any region. Our findings of lower V(T) in AD versus HC in multiple regions are in contrast to findings in the mu and delta opioid receptor systems of higher V(T) in AD versus HC. Although age-related decline in receptors has previously been observed in the mu opioid receptor system, we found that KOR availability does not change with age. Springer International Publishing 2018-09-06 2018-12 /pmc/articles/PMC6224533/ /pubmed/30188515 http://dx.doi.org/10.1038/s41386-018-0199-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Vijay, Aishwarya
Cavallo, Dana
Goldberg, Alissa
de Laat, Bart
Nabulsi, Nabeel
Huang, Yiyun
Krishnan-Sarin, Suchitra
Morris, Evan D.
PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
title PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
title_full PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
title_fullStr PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
title_full_unstemmed PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
title_short PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
title_sort pet imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224533/
https://www.ncbi.nlm.nih.gov/pubmed/30188515
http://dx.doi.org/10.1038/s41386-018-0199-1
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