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Metabolite sensing and signaling in cell metabolism

Metabolite sensing is one of the most fundamental biological processes. During evolution, multilayered mechanisms developed to sense fluctuations in a wide spectrum of metabolites, including nutrients, to coordinate cellular metabolism and biological networks. To date, AMPK and mTOR signaling are am...

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Detalles Bibliográficos
Autores principales: Wang, Yi-Ping, Lei, Qun-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224561/
https://www.ncbi.nlm.nih.gov/pubmed/30416760
http://dx.doi.org/10.1038/s41392-018-0024-7
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author Wang, Yi-Ping
Lei, Qun-Ying
author_facet Wang, Yi-Ping
Lei, Qun-Ying
author_sort Wang, Yi-Ping
collection PubMed
description Metabolite sensing is one of the most fundamental biological processes. During evolution, multilayered mechanisms developed to sense fluctuations in a wide spectrum of metabolites, including nutrients, to coordinate cellular metabolism and biological networks. To date, AMPK and mTOR signaling are among the best-understood metabolite-sensing and signaling pathways. Here, we propose a sensor-transducer-effector model to describe known mechanisms of metabolite sensing and signaling. We define a metabolite sensor by its specificity, dynamicity, and functionality. We group the actions of metabolite sensing into three different modes: metabolite sensor-mediated signaling, metabolite-sensing module, and sensing by conjugating. With these modes of action, we provide a systematic view of how cells sense sugars, lipids, amino acids, and metabolic intermediates. In the future perspective, we suggest a systematic screen of metabolite-sensing macromolecules, high-throughput discovery of biomacromolecule-metabolite interactomes, and functional metabolomics to advance our knowledge of metabolite sensing and signaling. Most importantly, targeting metabolite sensing holds great promise in therapeutic intervention of metabolic diseases and in improving healthy aging.
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spelling pubmed-62245612018-11-09 Metabolite sensing and signaling in cell metabolism Wang, Yi-Ping Lei, Qun-Ying Signal Transduct Target Ther Review Article Metabolite sensing is one of the most fundamental biological processes. During evolution, multilayered mechanisms developed to sense fluctuations in a wide spectrum of metabolites, including nutrients, to coordinate cellular metabolism and biological networks. To date, AMPK and mTOR signaling are among the best-understood metabolite-sensing and signaling pathways. Here, we propose a sensor-transducer-effector model to describe known mechanisms of metabolite sensing and signaling. We define a metabolite sensor by its specificity, dynamicity, and functionality. We group the actions of metabolite sensing into three different modes: metabolite sensor-mediated signaling, metabolite-sensing module, and sensing by conjugating. With these modes of action, we provide a systematic view of how cells sense sugars, lipids, amino acids, and metabolic intermediates. In the future perspective, we suggest a systematic screen of metabolite-sensing macromolecules, high-throughput discovery of biomacromolecule-metabolite interactomes, and functional metabolomics to advance our knowledge of metabolite sensing and signaling. Most importantly, targeting metabolite sensing holds great promise in therapeutic intervention of metabolic diseases and in improving healthy aging. Nature Publishing Group UK 2018-11-09 /pmc/articles/PMC6224561/ /pubmed/30416760 http://dx.doi.org/10.1038/s41392-018-0024-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Wang, Yi-Ping
Lei, Qun-Ying
Metabolite sensing and signaling in cell metabolism
title Metabolite sensing and signaling in cell metabolism
title_full Metabolite sensing and signaling in cell metabolism
title_fullStr Metabolite sensing and signaling in cell metabolism
title_full_unstemmed Metabolite sensing and signaling in cell metabolism
title_short Metabolite sensing and signaling in cell metabolism
title_sort metabolite sensing and signaling in cell metabolism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224561/
https://www.ncbi.nlm.nih.gov/pubmed/30416760
http://dx.doi.org/10.1038/s41392-018-0024-7
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