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Metabolite sensing and signaling in cell metabolism
Metabolite sensing is one of the most fundamental biological processes. During evolution, multilayered mechanisms developed to sense fluctuations in a wide spectrum of metabolites, including nutrients, to coordinate cellular metabolism and biological networks. To date, AMPK and mTOR signaling are am...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224561/ https://www.ncbi.nlm.nih.gov/pubmed/30416760 http://dx.doi.org/10.1038/s41392-018-0024-7 |
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author | Wang, Yi-Ping Lei, Qun-Ying |
author_facet | Wang, Yi-Ping Lei, Qun-Ying |
author_sort | Wang, Yi-Ping |
collection | PubMed |
description | Metabolite sensing is one of the most fundamental biological processes. During evolution, multilayered mechanisms developed to sense fluctuations in a wide spectrum of metabolites, including nutrients, to coordinate cellular metabolism and biological networks. To date, AMPK and mTOR signaling are among the best-understood metabolite-sensing and signaling pathways. Here, we propose a sensor-transducer-effector model to describe known mechanisms of metabolite sensing and signaling. We define a metabolite sensor by its specificity, dynamicity, and functionality. We group the actions of metabolite sensing into three different modes: metabolite sensor-mediated signaling, metabolite-sensing module, and sensing by conjugating. With these modes of action, we provide a systematic view of how cells sense sugars, lipids, amino acids, and metabolic intermediates. In the future perspective, we suggest a systematic screen of metabolite-sensing macromolecules, high-throughput discovery of biomacromolecule-metabolite interactomes, and functional metabolomics to advance our knowledge of metabolite sensing and signaling. Most importantly, targeting metabolite sensing holds great promise in therapeutic intervention of metabolic diseases and in improving healthy aging. |
format | Online Article Text |
id | pubmed-6224561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62245612018-11-09 Metabolite sensing and signaling in cell metabolism Wang, Yi-Ping Lei, Qun-Ying Signal Transduct Target Ther Review Article Metabolite sensing is one of the most fundamental biological processes. During evolution, multilayered mechanisms developed to sense fluctuations in a wide spectrum of metabolites, including nutrients, to coordinate cellular metabolism and biological networks. To date, AMPK and mTOR signaling are among the best-understood metabolite-sensing and signaling pathways. Here, we propose a sensor-transducer-effector model to describe known mechanisms of metabolite sensing and signaling. We define a metabolite sensor by its specificity, dynamicity, and functionality. We group the actions of metabolite sensing into three different modes: metabolite sensor-mediated signaling, metabolite-sensing module, and sensing by conjugating. With these modes of action, we provide a systematic view of how cells sense sugars, lipids, amino acids, and metabolic intermediates. In the future perspective, we suggest a systematic screen of metabolite-sensing macromolecules, high-throughput discovery of biomacromolecule-metabolite interactomes, and functional metabolomics to advance our knowledge of metabolite sensing and signaling. Most importantly, targeting metabolite sensing holds great promise in therapeutic intervention of metabolic diseases and in improving healthy aging. Nature Publishing Group UK 2018-11-09 /pmc/articles/PMC6224561/ /pubmed/30416760 http://dx.doi.org/10.1038/s41392-018-0024-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Wang, Yi-Ping Lei, Qun-Ying Metabolite sensing and signaling in cell metabolism |
title | Metabolite sensing and signaling in cell metabolism |
title_full | Metabolite sensing and signaling in cell metabolism |
title_fullStr | Metabolite sensing and signaling in cell metabolism |
title_full_unstemmed | Metabolite sensing and signaling in cell metabolism |
title_short | Metabolite sensing and signaling in cell metabolism |
title_sort | metabolite sensing and signaling in cell metabolism |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224561/ https://www.ncbi.nlm.nih.gov/pubmed/30416760 http://dx.doi.org/10.1038/s41392-018-0024-7 |
work_keys_str_mv | AT wangyiping metabolitesensingandsignalingincellmetabolism AT leiqunying metabolitesensingandsignalingincellmetabolism |