Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion

The ligand for the c-Kit receptor, KitL, exists as a membrane-associated (mKitL) and a soluble form (sKitL). KitL functions outside c-Kit activation have not been identified. We show that co-culture of c-Kit– and mKitL–expressing NIH3T3 cells results in signaling through mKitL: c-Kit–bound mKitL rec...

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Detalles Bibliográficos
Autores principales: Buono, Mario, Thézénas, Marie-Laëtitia, Ceroni, Alessandro, Fischer, Roman, Nerlov, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224562/
https://www.ncbi.nlm.nih.gov/pubmed/30410062
http://dx.doi.org/10.1038/s41467-018-07024-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224562/
https://www.ncbi.nlm.nih.gov/pubmed/30410062
http://dx.doi.org/10.1038/s41467-018-07024-0

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