Cargando…
Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations
Aging human tissues, such as sun-exposed epidermis, accumulate a high burden of progenitor cells that carry oncogenic mutations. However, most progenitors carrying such mutations colonize and persist in normal tissue without forming tumors. Here, we investigated tissue-level constraints on clonal pr...
Autores principales: | Murai, Kasumi, Skrupskelyte, Greta, Piedrafita, Gabriel, Hall, Michael, Kostiou, Vasiliki, Ong, Swee Hoe, Nagy, Tibor, Cagan, Alex, Goulding, David, Klein, Allon M., Hall, Benjamin A., Jones, Philip H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224607/ https://www.ncbi.nlm.nih.gov/pubmed/30269904 http://dx.doi.org/10.1016/j.stem.2018.08.017 |
Ejemplares similares
-
A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice
por: Piedrafita, Gabriel, et al.
Publicado: (2020) -
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition
por: Murai, Kasumi, et al.
Publicado: (2022) -
Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
por: Fernandez-Antoran, David, et al.
Publicado: (2019) -
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
por: Abby, Emilie, et al.
Publicado: (2023) -
Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia
por: Kostiou, Vasiliki, et al.
Publicado: (2021)