New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs

Five new naphthalene derivatives, named Eleutherols A–C (1–3) and Eleuthinones B–C (4,5), together with three known compounds were isolated from the bulbs of Eleutherine americana. Their structures were elucidated on the basis of spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR techniques....

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Autores principales: Chen, De-Li, Hu, Mei-Geng, Liu, Yang-Yang, Li, Rong-Tao, Yu, Meng, Xu, Xu-Dong, Ma, Guo-Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225190/
https://www.ncbi.nlm.nih.gov/pubmed/30135380
http://dx.doi.org/10.3390/molecules23092111
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author Chen, De-Li
Hu, Mei-Geng
Liu, Yang-Yang
Li, Rong-Tao
Yu, Meng
Xu, Xu-Dong
Ma, Guo-Xu
author_facet Chen, De-Li
Hu, Mei-Geng
Liu, Yang-Yang
Li, Rong-Tao
Yu, Meng
Xu, Xu-Dong
Ma, Guo-Xu
author_sort Chen, De-Li
collection PubMed
description Five new naphthalene derivatives, named Eleutherols A–C (1–3) and Eleuthinones B–C (4,5), together with three known compounds were isolated from the bulbs of Eleutherine americana. Their structures were elucidated on the basis of spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR techniques. These compounds exhibited a potent effect against the injury of human umbilical vein endothelial cell (HUVECs) induced by high concentrations of glucose in vitro.
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spelling pubmed-62251902018-11-13 New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs Chen, De-Li Hu, Mei-Geng Liu, Yang-Yang Li, Rong-Tao Yu, Meng Xu, Xu-Dong Ma, Guo-Xu Molecules Article Five new naphthalene derivatives, named Eleutherols A–C (1–3) and Eleuthinones B–C (4,5), together with three known compounds were isolated from the bulbs of Eleutherine americana. Their structures were elucidated on the basis of spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR techniques. These compounds exhibited a potent effect against the injury of human umbilical vein endothelial cell (HUVECs) induced by high concentrations of glucose in vitro. MDPI 2018-08-22 /pmc/articles/PMC6225190/ /pubmed/30135380 http://dx.doi.org/10.3390/molecules23092111 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, De-Li
Hu, Mei-Geng
Liu, Yang-Yang
Li, Rong-Tao
Yu, Meng
Xu, Xu-Dong
Ma, Guo-Xu
New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs
title New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs
title_full New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs
title_fullStr New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs
title_full_unstemmed New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs
title_short New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs
title_sort new naphthalene derivatives from the bulbs of eleutherine americana with their protective effect on the injury of huvecs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225190/
https://www.ncbi.nlm.nih.gov/pubmed/30135380
http://dx.doi.org/10.3390/molecules23092111
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