Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae

Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds w...

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Autores principales: Hegazy, Mohamed-Elamir F., Hamed, Ahmed R., Ibrahim, Mahmoud A. A., Talat, Zienab, Reda, Eman H., Abdel-Azim, Nahla S., Hammouda, Faiza M., Nakamura, Seikou, Matsuda, Hisashi, Haggag, Eman G., Paré, Paul W., Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225227/
https://www.ncbi.nlm.nih.gov/pubmed/30200407
http://dx.doi.org/10.3390/molecules23092221
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author Hegazy, Mohamed-Elamir F.
Hamed, Ahmed R.
Ibrahim, Mahmoud A. A.
Talat, Zienab
Reda, Eman H.
Abdel-Azim, Nahla S.
Hammouda, Faiza M.
Nakamura, Seikou
Matsuda, Hisashi
Haggag, Eman G.
Paré, Paul W.
Efferth, Thomas
author_facet Hegazy, Mohamed-Elamir F.
Hamed, Ahmed R.
Ibrahim, Mahmoud A. A.
Talat, Zienab
Reda, Eman H.
Abdel-Azim, Nahla S.
Hammouda, Faiza M.
Nakamura, Seikou
Matsuda, Hisashi
Haggag, Eman G.
Paré, Paul W.
Efferth, Thomas
author_sort Hegazy, Mohamed-Elamir F.
collection PubMed
description Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC(50) = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.
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spelling pubmed-62252272018-11-13 Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae Hegazy, Mohamed-Elamir F. Hamed, Ahmed R. Ibrahim, Mahmoud A. A. Talat, Zienab Reda, Eman H. Abdel-Azim, Nahla S. Hammouda, Faiza M. Nakamura, Seikou Matsuda, Hisashi Haggag, Eman G. Paré, Paul W. Efferth, Thomas Molecules Article Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC(50) = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra. MDPI 2018-09-01 /pmc/articles/PMC6225227/ /pubmed/30200407 http://dx.doi.org/10.3390/molecules23092221 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hegazy, Mohamed-Elamir F.
Hamed, Ahmed R.
Ibrahim, Mahmoud A. A.
Talat, Zienab
Reda, Eman H.
Abdel-Azim, Nahla S.
Hammouda, Faiza M.
Nakamura, Seikou
Matsuda, Hisashi
Haggag, Eman G.
Paré, Paul W.
Efferth, Thomas
Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
title Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
title_full Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
title_fullStr Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
title_full_unstemmed Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
title_short Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
title_sort euphosantianane a–d: antiproliferative premyrsinane diterpenoids from the endemic egyptian plant euphorbia sanctae-catharinae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225227/
https://www.ncbi.nlm.nih.gov/pubmed/30200407
http://dx.doi.org/10.3390/molecules23092221
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