K(2)S(2)O(8)-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source

Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good...

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Detalles Bibliográficos
Autores principales: Bian, Yongjun, Qu, Xingyu, Chen, Yongqiang, Li, Jun, Liu, Leng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225268/
https://www.ncbi.nlm.nih.gov/pubmed/30200457
http://dx.doi.org/10.3390/molecules23092225
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author Bian, Yongjun
Qu, Xingyu
Chen, Yongqiang
Li, Jun
Liu, Leng
author_facet Bian, Yongjun
Qu, Xingyu
Chen, Yongqiang
Li, Jun
Liu, Leng
author_sort Bian, Yongjun
collection PubMed
description Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.
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spelling pubmed-62252682018-11-13 K(2)S(2)O(8)-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source Bian, Yongjun Qu, Xingyu Chen, Yongqiang Li, Jun Liu, Leng Molecules Article Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition. MDPI 2018-09-01 /pmc/articles/PMC6225268/ /pubmed/30200457 http://dx.doi.org/10.3390/molecules23092225 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bian, Yongjun
Qu, Xingyu
Chen, Yongqiang
Li, Jun
Liu, Leng
K(2)S(2)O(8)-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source
title K(2)S(2)O(8)-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source
title_full K(2)S(2)O(8)-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source
title_fullStr K(2)S(2)O(8)-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source
title_full_unstemmed K(2)S(2)O(8)-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source
title_short K(2)S(2)O(8)-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source
title_sort k(2)s(2)o(8)-promoted aryl thioamides synthesis from aryl aldehydes using thiourea as the sulfur source
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225268/
https://www.ncbi.nlm.nih.gov/pubmed/30200457
http://dx.doi.org/10.3390/molecules23092225
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