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Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV(1), Glutamate, and Opioid Receptors

Pain is one of the most common cause for hospital visits. It plays an important role in inflammation and serves as a warning sign to avoid further injury. Analgesics are used to manage pain and provide comfort to patients. However, prolonged usage of pain treatments like opioids and NSAIDs are accom...

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Autores principales: Ping, Chung Pui, Tengku Mohamad, Tengku Azam Shah, Akhtar, Muhammad Nadeem, Perimal, Enoch Kumar, Akira, Ahmad, Israf Ali, Daud Ahmad, Sulaiman, Mohd Roslan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225316/
https://www.ncbi.nlm.nih.gov/pubmed/30177603
http://dx.doi.org/10.3390/molecules23092237
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author Ping, Chung Pui
Tengku Mohamad, Tengku Azam Shah
Akhtar, Muhammad Nadeem
Perimal, Enoch Kumar
Akira, Ahmad
Israf Ali, Daud Ahmad
Sulaiman, Mohd Roslan
author_facet Ping, Chung Pui
Tengku Mohamad, Tengku Azam Shah
Akhtar, Muhammad Nadeem
Perimal, Enoch Kumar
Akira, Ahmad
Israf Ali, Daud Ahmad
Sulaiman, Mohd Roslan
author_sort Ping, Chung Pui
collection PubMed
description Pain is one of the most common cause for hospital visits. It plays an important role in inflammation and serves as a warning sign to avoid further injury. Analgesics are used to manage pain and provide comfort to patients. However, prolonged usage of pain treatments like opioids and NSAIDs are accompanied with undesirable side effects. Therefore, research to identify novel compounds that produce analgesia with lesser side effects are necessary. The present study investigated the antinociceptive potentials of a natural compound, cardamonin, isolated from Boesenbergia rotunda (L) Mansf. using chemical and thermal models of nociception. Our findings showed that intraperitoneal and oral administration of cardamonin (0.3, 1, 3, and 10 mg/kg) produced significant and dose-dependent inhibition of pain in abdominal writhing responses induced by acetic acid. The present study also demonstrated that cardamonin produced significant analgesia in formalin-, capsaicin-, and glutamate-induced paw licking tests. In the thermal-induced nociception model, cardamonin exhibited significant increase in response latency time of animals subjected to hot-plate thermal stimuli. The rota-rod assessment confirmed that the antinociceptive activities elicited by cardamonin was not related to muscle relaxant or sedative effects of the compound. In conclusion, the present findings showed that cardamonin exerted significant peripheral and central antinociception through chemical- and thermal-induced nociception in mice through the involvement of TRPV(1), glutamate, and opioid receptors.
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spelling pubmed-62253162018-11-13 Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV(1), Glutamate, and Opioid Receptors Ping, Chung Pui Tengku Mohamad, Tengku Azam Shah Akhtar, Muhammad Nadeem Perimal, Enoch Kumar Akira, Ahmad Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan Molecules Article Pain is one of the most common cause for hospital visits. It plays an important role in inflammation and serves as a warning sign to avoid further injury. Analgesics are used to manage pain and provide comfort to patients. However, prolonged usage of pain treatments like opioids and NSAIDs are accompanied with undesirable side effects. Therefore, research to identify novel compounds that produce analgesia with lesser side effects are necessary. The present study investigated the antinociceptive potentials of a natural compound, cardamonin, isolated from Boesenbergia rotunda (L) Mansf. using chemical and thermal models of nociception. Our findings showed that intraperitoneal and oral administration of cardamonin (0.3, 1, 3, and 10 mg/kg) produced significant and dose-dependent inhibition of pain in abdominal writhing responses induced by acetic acid. The present study also demonstrated that cardamonin produced significant analgesia in formalin-, capsaicin-, and glutamate-induced paw licking tests. In the thermal-induced nociception model, cardamonin exhibited significant increase in response latency time of animals subjected to hot-plate thermal stimuli. The rota-rod assessment confirmed that the antinociceptive activities elicited by cardamonin was not related to muscle relaxant or sedative effects of the compound. In conclusion, the present findings showed that cardamonin exerted significant peripheral and central antinociception through chemical- and thermal-induced nociception in mice through the involvement of TRPV(1), glutamate, and opioid receptors. MDPI 2018-09-03 /pmc/articles/PMC6225316/ /pubmed/30177603 http://dx.doi.org/10.3390/molecules23092237 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ping, Chung Pui
Tengku Mohamad, Tengku Azam Shah
Akhtar, Muhammad Nadeem
Perimal, Enoch Kumar
Akira, Ahmad
Israf Ali, Daud Ahmad
Sulaiman, Mohd Roslan
Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV(1), Glutamate, and Opioid Receptors
title Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV(1), Glutamate, and Opioid Receptors
title_full Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV(1), Glutamate, and Opioid Receptors
title_fullStr Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV(1), Glutamate, and Opioid Receptors
title_full_unstemmed Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV(1), Glutamate, and Opioid Receptors
title_short Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV(1), Glutamate, and Opioid Receptors
title_sort antinociceptive effects of cardamonin in mice: possible involvement of trpv(1), glutamate, and opioid receptors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225316/
https://www.ncbi.nlm.nih.gov/pubmed/30177603
http://dx.doi.org/10.3390/molecules23092237
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