Cargando…

Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial

BACKGROUND: Increased levels of reactive oxygen species is a key factor involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Coenzyme Q(10) (CoQ(10)) is a nonenzymatic antioxidant that restores other antioxidants. MATERIALS AND METHODS: This randomized, double-blind placebo-controlled tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zarei, Parvin, Rezvanfar, Mohammad Reza, Ansarihadipour, Hadi, Delavar, Mostafa, Abdollahi, Mahdi, Khosrowbeygi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225443/
https://www.ncbi.nlm.nih.gov/pubmed/30505329
http://dx.doi.org/10.4103/jrms.JRMS_970_17
_version_ 1783369777267343360
author Zarei, Parvin
Rezvanfar, Mohammad Reza
Ansarihadipour, Hadi
Delavar, Mostafa
Abdollahi, Mahdi
Khosrowbeygi, Ali
author_facet Zarei, Parvin
Rezvanfar, Mohammad Reza
Ansarihadipour, Hadi
Delavar, Mostafa
Abdollahi, Mahdi
Khosrowbeygi, Ali
author_sort Zarei, Parvin
collection PubMed
description BACKGROUND: Increased levels of reactive oxygen species is a key factor involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Coenzyme Q(10) (CoQ(10)) is a nonenzymatic antioxidant that restores other antioxidants. MATERIALS AND METHODS: This randomized, double-blind placebo-controlled trial study has been designed to evaluate the effects of CoQ(10) supplementation on serum values of amylase, adenosine deaminase, catalase (CAT), total antioxidant capacity (TAC) and the quantitative insulin sensitivity check index (QUICKI) in women with T2DM. Serum levels of CoQ(10) were measured too. Sixty-eight women with T2DM were enrolled in this study and randomly divided into two groups. One group received 100 mg/day of CoQ(10) supplement for 12 weeks (n = 34), and the other group was given placebo for the same time duration and dosage (n = 34). RESULTS: After the intervention, serum CAT activity (P < 0.001), TAC (P = 0.006), CoQ(10) (P = 0.001), and QUICKI (P = 0.005) increased and fasting blood sugar (FBS) (P = 0.05) decreased significantly in CoQ(10) group. CONCLUSION: This study showed that daily supplementation with 100 mg of CoQ(10) could increase TAC and CAT activity as, CoQ(10) and QUICKI and could reduce oxidative stress and FBS in women with T2DM.
format Online
Article
Text
id pubmed-6225443
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-62254432018-11-30 Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial Zarei, Parvin Rezvanfar, Mohammad Reza Ansarihadipour, Hadi Delavar, Mostafa Abdollahi, Mahdi Khosrowbeygi, Ali J Res Med Sci Original Article BACKGROUND: Increased levels of reactive oxygen species is a key factor involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Coenzyme Q(10) (CoQ(10)) is a nonenzymatic antioxidant that restores other antioxidants. MATERIALS AND METHODS: This randomized, double-blind placebo-controlled trial study has been designed to evaluate the effects of CoQ(10) supplementation on serum values of amylase, adenosine deaminase, catalase (CAT), total antioxidant capacity (TAC) and the quantitative insulin sensitivity check index (QUICKI) in women with T2DM. Serum levels of CoQ(10) were measured too. Sixty-eight women with T2DM were enrolled in this study and randomly divided into two groups. One group received 100 mg/day of CoQ(10) supplement for 12 weeks (n = 34), and the other group was given placebo for the same time duration and dosage (n = 34). RESULTS: After the intervention, serum CAT activity (P < 0.001), TAC (P = 0.006), CoQ(10) (P = 0.001), and QUICKI (P = 0.005) increased and fasting blood sugar (FBS) (P = 0.05) decreased significantly in CoQ(10) group. CONCLUSION: This study showed that daily supplementation with 100 mg of CoQ(10) could increase TAC and CAT activity as, CoQ(10) and QUICKI and could reduce oxidative stress and FBS in women with T2DM. Medknow Publications & Media Pvt Ltd 2018-10-26 /pmc/articles/PMC6225443/ /pubmed/30505329 http://dx.doi.org/10.4103/jrms.JRMS_970_17 Text en Copyright: © 2018 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Zarei, Parvin
Rezvanfar, Mohammad Reza
Ansarihadipour, Hadi
Delavar, Mostafa
Abdollahi, Mahdi
Khosrowbeygi, Ali
Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
title Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
title_full Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
title_fullStr Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
title_full_unstemmed Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
title_short Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
title_sort effects of coenzyme q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: a randomized, double-blind placebo-controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225443/
https://www.ncbi.nlm.nih.gov/pubmed/30505329
http://dx.doi.org/10.4103/jrms.JRMS_970_17
work_keys_str_mv AT zareiparvin effectsofcoenzymeq10supplementationontheserumlevelsofamylaseadenosinedeaminasecatalaseandtotalantioxidantcapacityinwomenwithtype2diabetesmellitusarandomizeddoubleblindplacebocontrolledtrial
AT rezvanfarmohammadreza effectsofcoenzymeq10supplementationontheserumlevelsofamylaseadenosinedeaminasecatalaseandtotalantioxidantcapacityinwomenwithtype2diabetesmellitusarandomizeddoubleblindplacebocontrolledtrial
AT ansarihadipourhadi effectsofcoenzymeq10supplementationontheserumlevelsofamylaseadenosinedeaminasecatalaseandtotalantioxidantcapacityinwomenwithtype2diabetesmellitusarandomizeddoubleblindplacebocontrolledtrial
AT delavarmostafa effectsofcoenzymeq10supplementationontheserumlevelsofamylaseadenosinedeaminasecatalaseandtotalantioxidantcapacityinwomenwithtype2diabetesmellitusarandomizeddoubleblindplacebocontrolledtrial
AT abdollahimahdi effectsofcoenzymeq10supplementationontheserumlevelsofamylaseadenosinedeaminasecatalaseandtotalantioxidantcapacityinwomenwithtype2diabetesmellitusarandomizeddoubleblindplacebocontrolledtrial
AT khosrowbeygiali effectsofcoenzymeq10supplementationontheserumlevelsofamylaseadenosinedeaminasecatalaseandtotalantioxidantcapacityinwomenwithtype2diabetesmellitusarandomizeddoubleblindplacebocontrolledtrial