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Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
BACKGROUND: Increased levels of reactive oxygen species is a key factor involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Coenzyme Q(10) (CoQ(10)) is a nonenzymatic antioxidant that restores other antioxidants. MATERIALS AND METHODS: This randomized, double-blind placebo-controlled tr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225443/ https://www.ncbi.nlm.nih.gov/pubmed/30505329 http://dx.doi.org/10.4103/jrms.JRMS_970_17 |
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author | Zarei, Parvin Rezvanfar, Mohammad Reza Ansarihadipour, Hadi Delavar, Mostafa Abdollahi, Mahdi Khosrowbeygi, Ali |
author_facet | Zarei, Parvin Rezvanfar, Mohammad Reza Ansarihadipour, Hadi Delavar, Mostafa Abdollahi, Mahdi Khosrowbeygi, Ali |
author_sort | Zarei, Parvin |
collection | PubMed |
description | BACKGROUND: Increased levels of reactive oxygen species is a key factor involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Coenzyme Q(10) (CoQ(10)) is a nonenzymatic antioxidant that restores other antioxidants. MATERIALS AND METHODS: This randomized, double-blind placebo-controlled trial study has been designed to evaluate the effects of CoQ(10) supplementation on serum values of amylase, adenosine deaminase, catalase (CAT), total antioxidant capacity (TAC) and the quantitative insulin sensitivity check index (QUICKI) in women with T2DM. Serum levels of CoQ(10) were measured too. Sixty-eight women with T2DM were enrolled in this study and randomly divided into two groups. One group received 100 mg/day of CoQ(10) supplement for 12 weeks (n = 34), and the other group was given placebo for the same time duration and dosage (n = 34). RESULTS: After the intervention, serum CAT activity (P < 0.001), TAC (P = 0.006), CoQ(10) (P = 0.001), and QUICKI (P = 0.005) increased and fasting blood sugar (FBS) (P = 0.05) decreased significantly in CoQ(10) group. CONCLUSION: This study showed that daily supplementation with 100 mg of CoQ(10) could increase TAC and CAT activity as, CoQ(10) and QUICKI and could reduce oxidative stress and FBS in women with T2DM. |
format | Online Article Text |
id | pubmed-6225443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62254432018-11-30 Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial Zarei, Parvin Rezvanfar, Mohammad Reza Ansarihadipour, Hadi Delavar, Mostafa Abdollahi, Mahdi Khosrowbeygi, Ali J Res Med Sci Original Article BACKGROUND: Increased levels of reactive oxygen species is a key factor involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Coenzyme Q(10) (CoQ(10)) is a nonenzymatic antioxidant that restores other antioxidants. MATERIALS AND METHODS: This randomized, double-blind placebo-controlled trial study has been designed to evaluate the effects of CoQ(10) supplementation on serum values of amylase, adenosine deaminase, catalase (CAT), total antioxidant capacity (TAC) and the quantitative insulin sensitivity check index (QUICKI) in women with T2DM. Serum levels of CoQ(10) were measured too. Sixty-eight women with T2DM were enrolled in this study and randomly divided into two groups. One group received 100 mg/day of CoQ(10) supplement for 12 weeks (n = 34), and the other group was given placebo for the same time duration and dosage (n = 34). RESULTS: After the intervention, serum CAT activity (P < 0.001), TAC (P = 0.006), CoQ(10) (P = 0.001), and QUICKI (P = 0.005) increased and fasting blood sugar (FBS) (P = 0.05) decreased significantly in CoQ(10) group. CONCLUSION: This study showed that daily supplementation with 100 mg of CoQ(10) could increase TAC and CAT activity as, CoQ(10) and QUICKI and could reduce oxidative stress and FBS in women with T2DM. Medknow Publications & Media Pvt Ltd 2018-10-26 /pmc/articles/PMC6225443/ /pubmed/30505329 http://dx.doi.org/10.4103/jrms.JRMS_970_17 Text en Copyright: © 2018 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Zarei, Parvin Rezvanfar, Mohammad Reza Ansarihadipour, Hadi Delavar, Mostafa Abdollahi, Mahdi Khosrowbeygi, Ali Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial |
title | Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial |
title_full | Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial |
title_fullStr | Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial |
title_full_unstemmed | Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial |
title_short | Effects of coenzyme Q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial |
title_sort | effects of coenzyme q(10) supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: a randomized, double-blind placebo-controlled trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225443/ https://www.ncbi.nlm.nih.gov/pubmed/30505329 http://dx.doi.org/10.4103/jrms.JRMS_970_17 |
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