Cargando…
Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients
BACKGROUND: In high-fat diet-fed mice, interleukin-1 beta (IL-1 beta) has been shown to play a key role in hepatic steatosis. However, it remains unknown whether IL-1 beta could be associated with different grades of steatosis in obese humans. MATERIALS AND METHODS: Morbidly obese patients (n = 124)...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225445/ https://www.ncbi.nlm.nih.gov/pubmed/30505331 http://dx.doi.org/10.4103/jrms.JRMS_142_18 |
_version_ | 1783369777725571072 |
---|---|
author | Palomera, Leon F Gómez-Arauz, Angélica Y Villanueva-Ortega, Eréndira Meléndez-Mier, Guillermo Islas-Andrade, Sergio A Escobedo, Galileo |
author_facet | Palomera, Leon F Gómez-Arauz, Angélica Y Villanueva-Ortega, Eréndira Meléndez-Mier, Guillermo Islas-Andrade, Sergio A Escobedo, Galileo |
author_sort | Palomera, Leon F |
collection | PubMed |
description | BACKGROUND: In high-fat diet-fed mice, interleukin-1 beta (IL-1 beta) has been shown to play a key role in hepatic steatosis. However, it remains unknown whether IL-1 beta could be associated with different grades of steatosis in obese humans. MATERIALS AND METHODS: Morbidly obese patients (n = 124) aged 18–65 years were divided into four groups: no steatosis (controls), mild steatosis, moderate steatosis, and severe steatosis using abdominal ultrasound. IL-1 beta serum levels and liver function tests were measured and significant differences were estimated by one-way ANOVA followed by Tukey test. RESULTS: IL-1 beta serum levels significantly increased in morbidly obese patients with mild (11.38 ± 2.40 pg/ml), moderate (16.72 ± 2.47 pg/ml), and severe steatosis (23.29 ± 5.2 pg/ml) as compared to controls (7.78 ± 2.26 pg/ml). Liver function tests did not significantly change among different grades of steatosis. CONCLUSION: IL-1 beta serum levels associate better with steatosis degree than liver function tests in morbidly obese population. |
format | Online Article Text |
id | pubmed-6225445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62254452018-11-30 Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients Palomera, Leon F Gómez-Arauz, Angélica Y Villanueva-Ortega, Eréndira Meléndez-Mier, Guillermo Islas-Andrade, Sergio A Escobedo, Galileo J Res Med Sci Short Communication BACKGROUND: In high-fat diet-fed mice, interleukin-1 beta (IL-1 beta) has been shown to play a key role in hepatic steatosis. However, it remains unknown whether IL-1 beta could be associated with different grades of steatosis in obese humans. MATERIALS AND METHODS: Morbidly obese patients (n = 124) aged 18–65 years were divided into four groups: no steatosis (controls), mild steatosis, moderate steatosis, and severe steatosis using abdominal ultrasound. IL-1 beta serum levels and liver function tests were measured and significant differences were estimated by one-way ANOVA followed by Tukey test. RESULTS: IL-1 beta serum levels significantly increased in morbidly obese patients with mild (11.38 ± 2.40 pg/ml), moderate (16.72 ± 2.47 pg/ml), and severe steatosis (23.29 ± 5.2 pg/ml) as compared to controls (7.78 ± 2.26 pg/ml). Liver function tests did not significantly change among different grades of steatosis. CONCLUSION: IL-1 beta serum levels associate better with steatosis degree than liver function tests in morbidly obese population. Medknow Publications & Media Pvt Ltd 2018-10-26 /pmc/articles/PMC6225445/ /pubmed/30505331 http://dx.doi.org/10.4103/jrms.JRMS_142_18 Text en Copyright: © 2018 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Short Communication Palomera, Leon F Gómez-Arauz, Angélica Y Villanueva-Ortega, Eréndira Meléndez-Mier, Guillermo Islas-Andrade, Sergio A Escobedo, Galileo Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients |
title | Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients |
title_full | Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients |
title_fullStr | Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients |
title_full_unstemmed | Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients |
title_short | Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients |
title_sort | serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225445/ https://www.ncbi.nlm.nih.gov/pubmed/30505331 http://dx.doi.org/10.4103/jrms.JRMS_142_18 |
work_keys_str_mv | AT palomeraleonf serumlevelsofinterleukin1betaassociatebetterwithseverityofsimplesteatosisthanliverfunctiontestsinmorbidlyobesepatients AT gomezarauzangelicay serumlevelsofinterleukin1betaassociatebetterwithseverityofsimplesteatosisthanliverfunctiontestsinmorbidlyobesepatients AT villanuevaortegaerendira serumlevelsofinterleukin1betaassociatebetterwithseverityofsimplesteatosisthanliverfunctiontestsinmorbidlyobesepatients AT melendezmierguillermo serumlevelsofinterleukin1betaassociatebetterwithseverityofsimplesteatosisthanliverfunctiontestsinmorbidlyobesepatients AT islasandradesergioa serumlevelsofinterleukin1betaassociatebetterwithseverityofsimplesteatosisthanliverfunctiontestsinmorbidlyobesepatients AT escobedogalileo serumlevelsofinterleukin1betaassociatebetterwithseverityofsimplesteatosisthanliverfunctiontestsinmorbidlyobesepatients |