Aminoglycosides rapidly inhibit NAD(P)H metabolism increasing reactive oxygen species and cochlear cell demise

Despite causing permanent hearing loss by damaging inner ear sensory cells, aminoglycosides (AGs) remain one of the most widely used classes of antibiotics in the world. Although the mechanisms of cochlear sensory cell damage are not fully known, reactive oxygen species (ROS) are clearly implicated....

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Detalles Bibliográficos
Autores principales: Desa, Danielle E., Nichols, Michael G., Smith, Heather Jensen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2018
Materias:
Special Section on Metabolic Imaging and Spectroscopy: Britton Chance 105th Birthday Commemorative
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225535/
https://www.ncbi.nlm.nih.gov/pubmed/30411553
http://dx.doi.org/10.1117/1.JBO.24.5.051403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225535/
https://www.ncbi.nlm.nih.gov/pubmed/30411553
http://dx.doi.org/10.1117/1.JBO.24.5.051403

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