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Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer’s disease

Pathologic, biochemical and genetic evidence indicates that accumulation and aggregation of amyloid β-proteins (Aβ) is a critical factor in the pathogenesis of Alzheimer’s disease (AD). Several therapeutic interventions attempting to lower Aβ have failed to ameliorate cognitive decline in patients w...

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Detalles Bibliográficos
Autores principales:	Li, Shaomin, Jin, Ming, Liu, Lei, Dang, Yifan, Ostaszewski, Beth L., Selkoe, Dennis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225562/ https://www.ncbi.nlm.nih.gov/pubmed/30409172 http://dx.doi.org/10.1186/s40478-018-0626-x

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