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Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible

BACKGROUND: Mycoplasma pneumoniae pneumonia (MPP), or “walking pneumonia,” is an atypical mild disease with varied clinical findings. Specifically, diagnosis is often controversial and understanding of disease presentation is limited. The goal of the study was to evaluate presentation, clinical asso...

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Autores principales: Bajantri, Bharat, Toolsie, Omesh, Venkatram, Sindhaghatta, Diaz-Fuentes, Gilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225856/
https://www.ncbi.nlm.nih.gov/pubmed/30425761
http://dx.doi.org/10.14740/jocmr3592w
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author Bajantri, Bharat
Toolsie, Omesh
Venkatram, Sindhaghatta
Diaz-Fuentes, Gilda
author_facet Bajantri, Bharat
Toolsie, Omesh
Venkatram, Sindhaghatta
Diaz-Fuentes, Gilda
author_sort Bajantri, Bharat
collection PubMed
description BACKGROUND: Mycoplasma pneumoniae pneumonia (MPP), or “walking pneumonia,” is an atypical mild disease with varied clinical findings. Specifically, diagnosis is often controversial and understanding of disease presentation is limited. The goal of the study was to evaluate presentation, clinical associations and outcomes of MPP patients admitted to an inner-city hospital. METHODS: This was a retrospective analysis of adult patients diagnosed with MPP from January 2010 to January 2017. Primary outcomes were need for intensive care unit (ICU) care, ICU and hospital length of stay (LOS), presence of shock and need for mechanical ventilation (MV). Predictors of mortality were analyzed. RESULTS: Of the 203 patients analyzed, 16 (8%) died. Relative to survivors, non-survivors were older (65 ± 21 versus 53 ± 18, P = 0.009) and less frequently had obstructive airway disease (OAD; P = 0.003). Non-survivors also had significantly higher serum levels of lactic dehydrogenase (LDH), blood urea nitrogen (BUN), creatinine, transaminases and troponins. Finally, non-survivors more commonly exhibited shock, need for MV and bilateral lung infiltrates. There were no group differences in patient comorbidities, symptoms, antibiotic use or LOS. Predictors of mortality included age, OAD, low CD4(+) T-cell counts in human immunodeficiency virus-infected patients and elevated serum levels of LDH, creatinine, BUN, leukocytes, transaminases and troponins. CONCLUSION: Despite the availability of appropriate antibiotics, MPP incurs significant mortality and morbidity. Our study indicated that the recommended treatment includes prompt serological diagnosis, aggressive supportive care and presumptive antibiotics, especially in patients with poor prognosis.
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spelling pubmed-62258562018-11-13 Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible Bajantri, Bharat Toolsie, Omesh Venkatram, Sindhaghatta Diaz-Fuentes, Gilda J Clin Med Res Original Article BACKGROUND: Mycoplasma pneumoniae pneumonia (MPP), or “walking pneumonia,” is an atypical mild disease with varied clinical findings. Specifically, diagnosis is often controversial and understanding of disease presentation is limited. The goal of the study was to evaluate presentation, clinical associations and outcomes of MPP patients admitted to an inner-city hospital. METHODS: This was a retrospective analysis of adult patients diagnosed with MPP from January 2010 to January 2017. Primary outcomes were need for intensive care unit (ICU) care, ICU and hospital length of stay (LOS), presence of shock and need for mechanical ventilation (MV). Predictors of mortality were analyzed. RESULTS: Of the 203 patients analyzed, 16 (8%) died. Relative to survivors, non-survivors were older (65 ± 21 versus 53 ± 18, P = 0.009) and less frequently had obstructive airway disease (OAD; P = 0.003). Non-survivors also had significantly higher serum levels of lactic dehydrogenase (LDH), blood urea nitrogen (BUN), creatinine, transaminases and troponins. Finally, non-survivors more commonly exhibited shock, need for MV and bilateral lung infiltrates. There were no group differences in patient comorbidities, symptoms, antibiotic use or LOS. Predictors of mortality included age, OAD, low CD4(+) T-cell counts in human immunodeficiency virus-infected patients and elevated serum levels of LDH, creatinine, BUN, leukocytes, transaminases and troponins. CONCLUSION: Despite the availability of appropriate antibiotics, MPP incurs significant mortality and morbidity. Our study indicated that the recommended treatment includes prompt serological diagnosis, aggressive supportive care and presumptive antibiotics, especially in patients with poor prognosis. Elmer Press 2018-12 2018-10-30 /pmc/articles/PMC6225856/ /pubmed/30425761 http://dx.doi.org/10.14740/jocmr3592w Text en Copyright 2018, Bajantri et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bajantri, Bharat
Toolsie, Omesh
Venkatram, Sindhaghatta
Diaz-Fuentes, Gilda
Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible
title Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible
title_full Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible
title_fullStr Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible
title_full_unstemmed Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible
title_short Mycoplasma Pneumoniae Pneumonia: Walking Pneumonia Can Cripple the Susceptible
title_sort mycoplasma pneumoniae pneumonia: walking pneumonia can cripple the susceptible
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225856/
https://www.ncbi.nlm.nih.gov/pubmed/30425761
http://dx.doi.org/10.14740/jocmr3592w
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