Cargando…

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

Mutations of the mitochondrial genome (mtDNA) underlie a significant portion of mitochondrial disease burden. These disorders are currently incurable and effectively untreatable, with heterogeneous penetrance, presentation and prognosis. To address the lack of effective treatment for these disorders...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gammage, Payam A., Viscomi, Carlo, Simard, Marie-Lune, Costa, Ana S.H., Gaude, Edoardo, Powell, Christopher A., Van Haute, Lindsey, McCann, Beverly J., Rebelo-Guiomar, Pedro, Cerutti, Raffaele, Zhang, Lei, Rebar, Edward J., Zeviani, Massimo, Frezza, Christian, Stewart, James B., Minczuk, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225988/ https://www.ncbi.nlm.nih.gov/pubmed/30250142 http://dx.doi.org/10.1038/s41591-018-0165-9

Ejemplares similares

Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs
por: Gammage, Payam A., et al.
Publicado: (2016)

MtDNA-maintenance defects: syndromes and genes
por: Viscomi, Carlo, et al.
Publicado: (2017)

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions
por: Rebelo, Adriana P., et al.
Publicado: (2009)

The mammalian mitochondrial epitranscriptome()
por: Rebelo-Guiomar, Pedro, et al.
Publicado: (2019)

Partial tandem duplication of mtDNA–tRNA(Phe) impairs mtDNA translation in late-onset mitochondrial myopathy
por: Arzuffi, Paola, et al.
Publicado: (2012)

miRNAs in mtDNA-less cell mitochondria
por: Dasgupta, N, et al.
Publicado: (2015)

YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria
por: D’Souza, Aaron R, et al.
Publicado: (2021)

Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice
por: Viscomi, Carlo, et al.
Publicado: (2009)

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease
por: Nicholls, Thomas J., et al.
Publicado: (2014)

PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness
por: Rabas, Nicolas, et al.
Publicado: (2021)

Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family
por: Kullar, Peter J, et al.
Publicado: (2018)

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
por: Andreazza, Simonetta, et al.
Publicado: (2019)

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations
por: Gammage, Payam A, et al.
Publicado: (2014)

High Doses of Pesticides Induce mtDNA Damage in Intact Mitochondria of Potato In Vitro and Do Not Impact on mtDNA Integrity of Mitochondria of Shoots and Tubers under In Vivo Exposure
por: Alimova, Alina A., et al.
Publicado: (2022)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations
por: Hoitzing, Hanne, et al.
Publicado: (2019)

Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5-Formylcytosine Modification in Mitochondrial tRNA(Met)
por: Van Haute, Lindsey, et al.
Publicado: (2017)

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
por: Suissa, Sarit, et al.
Publicado: (2009)

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease
por: Kauppila, Johanna H.K., et al.
Publicado: (2016)

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
por: Gaude, Edoardo, et al.
Publicado: (2018)

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
por: Matic, Stanka, et al.
Publicado: (2018)

An improved method with a wider applicability to isolate plant mitochondria for mtDNA extraction
por: Ahmed, Zaheer, et al.
Publicado: (2015)

In Mitochondria β-Actin Regulates mtDNA Transcription and Is Required for Mitochondrial Quality Control
por: Xie, Xin, et al.
Publicado: (2018)

Mitochondria in tumour progression: a network of mtDNA variants in different types of cancer
por: Cavalcante, Giovanna C., et al.
Publicado: (2022)

DarT-mediated mtDNA damage induces dynamic reorganization and selective segregation of mitochondria
por: Dua, Nitish, et al.
Publicado: (2022)

TEFM (c17orf42) is necessary for transcription of human mtDNA
por: Minczuk, Michal, et al.
Publicado: (2011)

Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances
por: Pearce, Sarah F., et al.
Publicado: (2017)

Where mtDNA is made
por: LeBrasseur, Nicole
Publicado: (2003)

Melanesian mtDNA Complexity
por: Friedlaender, Jonathan S., et al.
Publicado: (2007)

Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance
por: Arthur, Charles R, et al.
Publicado: (2009)

TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts
por: Aasumets, Koit, et al.
Publicado: (2021)

C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome
por: Rorbach, Joanna, et al.
Publicado: (2012)

C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome
por: Rorbach, Joanna, et al.
Publicado: (2016)

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized
por: Gammage, Payam A., et al.
Publicado: (2018)

A549 cells contain enlarged mitochondria with independently functional clustered mtDNA nucleoids
por: Nasonovs, Aleksandrs, et al.
Publicado: (2021)

Mitochondrial DNA: the overlooked oncogenome?
por: Gammage, Payam A., et al.
Publicado: (2019)

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
por: van Tienen, Florence, et al.
Publicado: (2019)

Origins and Evolution of the Etruscans’ mtDNA
por: Ghirotto, Silvia, et al.
Publicado: (2013)

mtDNA in the Pathogenesis of Cardiovascular Diseases
por: Wang, Lili, et al.
Publicado: (2021)

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats
por: Chimienti, Guglielmina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_47dgvstq7fsstg622g8rn2ea6h