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The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions
Supplemental levels of vitamin B1 (thiamine) have been implicated in tumor progression. Tumor cells adaptively up-regulate thiamine transport during hypoxic stress. Upon uptake, thiamine pyrophosphokinase-1 (TPK1) facilitates the rapid phosphorylation of thiamine into thiamine pyrophosphate (TPP). H...
Autores principales: | Jonus, Hunter C., Hanberry, Bradley S., Khatu, Shivani, Kim, Jaeah, Luesch, Hendrik, Dang, Long H., Bartlett, Michael G., Zastre, Jason A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226039/ https://www.ncbi.nlm.nih.gov/pubmed/30459934 http://dx.doi.org/10.18632/oncotarget.26259 |
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