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Drug‐Drug Interaction Study of Apixaban with Cyclosporine and Tacrolimus in Healthy Volunteers

Apixaban is metabolized by cytochrome P450 (CYP) 3A4 in the liver and intestine, undergoes direct intestinal excretion, and is a substrate to permeability glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) transporters. We examined the drug interactions between cyclosporine and tacrolim...

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Detalles Bibliográficos
Autores principales:	Bashir, Babar, Stickle, Douglas F., Chervoneva, Inna, Kraft, Walter K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226116/ https://www.ncbi.nlm.nih.gov/pubmed/29972633 http://dx.doi.org/10.1111/cts.12580

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