Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

During development, transcriptional complexes at enhancers regulate gene expression in complex spatiotemporal patterns. To achieve robust expression without spurious activation, the affinity and specificity of transcription factor–DNA interactions must be precisely balanced. Protein–protein interact...

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Detalles Bibliográficos
Autores principales: Hope, C Matthew, Webber, Jemma L, Tokamov, Sherzod A, Rebay, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226293/
https://www.ncbi.nlm.nih.gov/pubmed/30412049
http://dx.doi.org/10.7554/eLife.37545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226293/
https://www.ncbi.nlm.nih.gov/pubmed/30412049
http://dx.doi.org/10.7554/eLife.37545

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