Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma

It remains unclear whether PAX6 acts as a crucial transcription factor for lung cancer stem cell (CSC) traits. We demonstrate that PAX6 acts as an oncogene responsible for induction of cancer stemness properties in lung adenocarcinoma (LUAD). Mechanistically, PAX6 promotes GLI transcription, resulti...

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Detalles Bibliográficos
Autores principales: Ooki, Akira, Dinalankara, Wikum, Marchionni, Luigi, Tsay, Jun-Chieh J., Goparaju, Chandra, Maleki, Zahra, Rom, William N., Pass, Harvey I., Hoque, Mohammad O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226336/
https://www.ncbi.nlm.nih.gov/pubmed/29980786
http://dx.doi.org/10.1038/s41388-018-0373-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226336/
https://www.ncbi.nlm.nih.gov/pubmed/29980786
http://dx.doi.org/10.1038/s41388-018-0373-2

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