Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway

Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log(10)CFU after two weeks of tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Upadhyay, Rashmi, Sanchez-Hidalgo, Andrea, Wilusz, Carol J., Lenaerts, Anne J., Arab, Jennifer, Yeh, Joanna, Stefanisko, Karen, Tarasova, Nadya I., Gonzalez-Juarrero, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226451/
https://www.ncbi.nlm.nih.gov/pubmed/30413750
http://dx.doi.org/10.1038/s41598-018-35023-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226451/
https://www.ncbi.nlm.nih.gov/pubmed/30413750
http://dx.doi.org/10.1038/s41598-018-35023-0

Ejemplares similares