Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1

Spongistatin 1 is among the most potent anti-proliferative agents ever discovered rendering it an attractive candidate for development as a payload for antibody–drug conjugates and other targeted delivery approaches. Unfortunately, it is unavailable from natural sources and its size and complex ster...

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Detalles Bibliográficos
Autores principales: Suen, Linda M., Tekle-Smith, Makeda A., Williamson, Kevin S., Infantine, Joshua R., Reznik, Samuel K., Tanis, Paul S., Casselman, Tyler D., Sackett, Dan L., Leighton, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226463/
https://www.ncbi.nlm.nih.gov/pubmed/30413713
http://dx.doi.org/10.1038/s41467-018-07259-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226463/
https://www.ncbi.nlm.nih.gov/pubmed/30413713
http://dx.doi.org/10.1038/s41467-018-07259-x

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