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Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
Spongistatin 1 is among the most potent anti-proliferative agents ever discovered rendering it an attractive candidate for development as a payload for antibody–drug conjugates and other targeted delivery approaches. Unfortunately, it is unavailable from natural sources and its size and complex ster...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226463/ https://www.ncbi.nlm.nih.gov/pubmed/30413713 http://dx.doi.org/10.1038/s41467-018-07259-x |