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Diffusion-limited association of disordered protein by non-native electrostatic interactions

Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins. In contrast to interactions between folded proteins, this additional folding step makes the binding process more complex. Understanding the mechanism of coupled binding and folding of IDPs requires analysis of b...

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Detalles Bibliográficos
Autores principales: Kim, Jae-Yeol, Meng, Fanjie, Yoo, Janghyun, Chung, Hoi Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226484/
https://www.ncbi.nlm.nih.gov/pubmed/30413699
http://dx.doi.org/10.1038/s41467-018-06866-y