NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts

The adaptor protein NUMB is involved in asymmetric division and cell fate determination and recognized as an antagonist of Notch. Previous studies have proved that Notch activation in osteoblasts contributes to a high bone mass. In this study,  however, an osteopenic phenotype was found in 9-week-ol...

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Detalles Bibliográficos
Autores principales: Ye, Ling, Lou, Feng, Yu, Fanyuan, Zhang, Demao, Wang, Chenglin, Wu, Fanzi, Li, Xin, Ping, Yilin, Yang, Xiao, Yang, Jing, Chen, Dian, Gao, Bo, Huang, Dingming, Liu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226489/
https://www.ncbi.nlm.nih.gov/pubmed/30455992
http://dx.doi.org/10.1038/s41413-018-0030-y

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