The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

PI3K/Akt signaling is activated in cancers and governs tumor initiation and progression, but how Akt is activated under diverse stresses is poorly understood. Here we identify AMPK as an essential regulator for Akt activation by various stresses. Surprisingly, AMPK is also activated by growth factor...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Fei, Li, Chien-Feng, Cai, Zhen, Zhang, Xian, Jin, Guoxiang, Zhang, Wei-Na, Xu, Chuan, Wang, Chi-Yun, Morrow, John, Zhang, Shuxing, Xu, Dazhi, Wang, Guihua, Lin, Hui-Kuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226490/
https://www.ncbi.nlm.nih.gov/pubmed/30413706
http://dx.doi.org/10.1038/s41467-018-07188-9

Ejemplares similares

Ejemplares similares