Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice

Prostaglandin (PG) D(2) is formed by two distinct PGD synthases (PGDS): lipocalin-type PGDS (L-PGDS), which acts as a PGD(2)-producing enzyme and as extracellular lipophilic transporter, and hematopoietic PGDS (H-PGDS), a σ glutathione-S-transferase. PGD(2) plays an important role in the maintenance...

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Detalles Bibliográficos
Autores principales: Song, Wen-Liang, Ricciotti, Emanuela, Liang, Xue, Grosser, Tilo, Grant, Gregory R., FitzGerald, Garret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:
Cardiovascular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226547/
https://www.ncbi.nlm.nih.gov/pubmed/30305427
http://dx.doi.org/10.1124/jpet.118.250936

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