Enhancing the Radiation Response in KRAS Mutant Colorectal Cancers Using the c-Met Inhibitor Crizotinib()()()

INTRODUCTION: C-Met plays important roles in treatment resistance, tumor invasion, and metastasis. In this study, we used a small molecule inhibitor of c-Met, crizotinib, in cetuximab-resistant, mutant KRAS-driven colorectal cancer cell lines and assessed radiosensitization. MATERIALS AND METHODS: A...

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Detalles Bibliográficos
Autores principales: Cuneo, Kyle C., Mehta, Ranjit K., Kurapati, Himabindu, Thomas, Dafydd G., Lawrence, Theodore S., Nyati, Mukesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226619/
https://www.ncbi.nlm.nih.gov/pubmed/30412912
http://dx.doi.org/10.1016/j.tranon.2018.10.005

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