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High Expression Levels of Fascin-1 Protein in Human Gliomas and its Clinical Relevance
INTRODUCTION: The fascin-1 protein is a cytoskeleton-like protein, which can prompt structural changes in cell membranes and affect the integrity of intercellular relations to promote invasion and metastasis of tumor cells. In this study, we researched the expression of fascin-1 in glioma. MATERIAL...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227898/ https://www.ncbi.nlm.nih.gov/pubmed/30426092 http://dx.doi.org/10.1515/med-2018-0080 |
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author | Zhang, Hao Cong, Qing-xue Zhang, Shan-guo Zhai, Xiu-wei Li, Hui-feng Li, Shuang-qi |
author_facet | Zhang, Hao Cong, Qing-xue Zhang, Shan-guo Zhai, Xiu-wei Li, Hui-feng Li, Shuang-qi |
author_sort | Zhang, Hao |
collection | PubMed |
description | INTRODUCTION: The fascin-1 protein is a cytoskeleton-like protein, which can prompt structural changes in cell membranes and affect the integrity of intercellular relations to promote invasion and metastasis of tumor cells. In this study, we researched the expression of fascin-1 in glioma. MATERIAL AND METHODS: The fascin-1 protein and mRNA were detected by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Then, we analyzed the relationship between the expression of fascin-1 protein and the clinical pathological characteristics of patients with glioma. Finally, the fascin-1 protein expression status and prognosis of glioma patients were investigated. RESULTS: The fascin-1 protein was mainly located in the cytoplasm of cells from glioma. The high expression rate of fascin-1 protein in glioma tissue was higher than that of normal brain tissue. At same time, we found that high fascin-1 protein expression was significantly correlated with World Health Organization (WHO) grading of glioma patients. The results survival analysis suggested high expression of fascin-1 protein in glioma patients with a shorter survival time. Multivariate analysis showed that high expression of fascin-1 protein was an independent predictor of the prognosis of patients with glioma. CONCLUSIONS: High expression of the fascin-1 protein indicates poor prognosis for glioma patients. |
format | Online Article Text |
id | pubmed-6227898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-62278982018-11-13 High Expression Levels of Fascin-1 Protein in Human Gliomas and its Clinical Relevance Zhang, Hao Cong, Qing-xue Zhang, Shan-guo Zhai, Xiu-wei Li, Hui-feng Li, Shuang-qi Open Med (Wars) Regular Articles INTRODUCTION: The fascin-1 protein is a cytoskeleton-like protein, which can prompt structural changes in cell membranes and affect the integrity of intercellular relations to promote invasion and metastasis of tumor cells. In this study, we researched the expression of fascin-1 in glioma. MATERIAL AND METHODS: The fascin-1 protein and mRNA were detected by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Then, we analyzed the relationship between the expression of fascin-1 protein and the clinical pathological characteristics of patients with glioma. Finally, the fascin-1 protein expression status and prognosis of glioma patients were investigated. RESULTS: The fascin-1 protein was mainly located in the cytoplasm of cells from glioma. The high expression rate of fascin-1 protein in glioma tissue was higher than that of normal brain tissue. At same time, we found that high fascin-1 protein expression was significantly correlated with World Health Organization (WHO) grading of glioma patients. The results survival analysis suggested high expression of fascin-1 protein in glioma patients with a shorter survival time. Multivariate analysis showed that high expression of fascin-1 protein was an independent predictor of the prognosis of patients with glioma. CONCLUSIONS: High expression of the fascin-1 protein indicates poor prognosis for glioma patients. De Gruyter 2018-10-25 /pmc/articles/PMC6227898/ /pubmed/30426092 http://dx.doi.org/10.1515/med-2018-0080 Text en © 2018 Hao Zhang et al., published by De Gruyter http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. |
spellingShingle | Regular Articles Zhang, Hao Cong, Qing-xue Zhang, Shan-guo Zhai, Xiu-wei Li, Hui-feng Li, Shuang-qi High Expression Levels of Fascin-1 Protein in Human Gliomas and its Clinical Relevance |
title | High Expression Levels of Fascin-1 Protein in Human Gliomas and its Clinical Relevance |
title_full | High Expression Levels of Fascin-1 Protein in Human Gliomas and its Clinical Relevance |
title_fullStr | High Expression Levels of Fascin-1 Protein in Human Gliomas and its Clinical Relevance |
title_full_unstemmed | High Expression Levels of Fascin-1 Protein in Human Gliomas and its Clinical Relevance |
title_short | High Expression Levels of Fascin-1 Protein in Human Gliomas and its Clinical Relevance |
title_sort | high expression levels of fascin-1 protein in human gliomas and its clinical relevance |
topic | Regular Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227898/ https://www.ncbi.nlm.nih.gov/pubmed/30426092 http://dx.doi.org/10.1515/med-2018-0080 |
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