Cargando…

Peptides derived from cadherin juxtamembrane region inhibit platelet function

The juxtamembrane domains (JMD) of transmembrane proteins are rich in critical peptide sequences that participate in dynamic cell signalling events. Synthetic JMD peptides derived from cadherin cell adhesion proteins have previously been shown to modulate platelet function. In this study, we aimed t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Golla, Kalyan, Stavropoulos, Ilias, Shields, Denis C., Moran, Niamh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2018
Materias:	Cellular and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227957/ https://www.ncbi.nlm.nih.gov/pubmed/30473799 http://dx.doi.org/10.1098/rsos.172347

Ejemplares similares

Cadherin juxtamembrane region derived peptides inhibit TGFβ1 induced gene expression
por: Stavropoulos, Ilias, et al.
Publicado: (2014)

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies
por: Lombardi, Federica, et al.
Publicado: (2015)

Structural Roles for the Juxtamembrane Linker Region and Transmembrane Region of Synaptobrevin 2 in Membrane Fusion
por: Hu, Yaru, et al.
Publicado: (2021)

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120(ctn)
por: Yap, Alpha S., et al.
Publicado: (1998)

Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin
por: Liu, Xiufen, et al.
Publicado: (2022)

ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets
por: Shpakova, Valentina, et al.
Publicado: (2022)

The juxtamembrane domain of the E-cadherin cytoplasmic tail contributes to its interaction with Myosin VI
por: Mangold, Sabine, et al.
Publicado: (2012)

Kv1.3 is the exclusive voltage-gated K(+) channel of platelets and megakaryocytes: roles in membrane potential, Ca(2+) signalling and platelet count
por: McCloskey, Conor, et al.
Publicado: (2010)

Requirement of the juxtamembrane domain of the cadherin cytoplasmic tail for morphogenetic cell rearrangement during myotome development
por: Horikawa, Kazuki, et al.
Publicado: (2001)

Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome
por: O’Brien, Kevin T., et al.
Publicado: (2019)

Prediction of polyproline II secondary structure propensity in proteins
por: O’Brien, Kevin T., et al.
Publicado: (2020)

Proteomic method to extract, concentrate, digest and enrich peptides from fossils with coloured (humic) substances for mass spectrometry analyses
por: Schroeter, Elena R., et al.
Publicado: (2019)

Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients
por: Nakashima, T, et al.
Publicado: (2003)

Enhanced antimicrobial peptide-induced activity in the mollusc Toll-2 family through evolution via tandem Toll/interleukin-1 receptor
por: Cao, Jun, et al.
Publicado: (2016)

A Potential Peptide Therapeutic Derived from the Juxtamembrane Domain of the Epidermal Growth Factor Receptor
por: Boran, Aislyn D. W., et al.
Publicado: (2012)

RNA-directed epigenetic silencing of Periostin inhibits cell motility
por: Lister, Nicholas C., et al.
Publicado: (2015)

Expression of S100A4, E-cadherin, α- and β-catenin in breast cancer biopsies
por: Pedersen, K B, et al.
Publicado: (2002)

Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis
por: Carucci, Nicoletta, et al.
Publicado: (2017)

IFITM proteins inhibit the late step of feline foamy virus replication
por: Kim, Jinsun, et al.
Publicado: (2020)

Thermodynamics and kinetics of the F(o)F(1)-ATPase: application of the probability isotherm
por: Chapman, Brian, et al.
Publicado: (2016)

The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors
por: Kornilov, F. D., et al.
Publicado: (2023)

Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE
por: Rathore, Shailendra S., et al.
Publicado: (2019)

Characterizing interaction between the juxtamembrane region of the single transmembrane protein and membrane using chemically synthesized peptides
por: Sato, Takeshi, et al.
Publicado: (2023)

Transcriptional impairment of β-catenin/E-cadherin complex is not associated with β-catenin mutations in colorectal carcinomas
por: Garinis, G A, et al.
Publicado: (2003)

Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression
por: Colpaert, C G, et al.
Publicado: (2003)

Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo
por: Jiao, W, et al.
Publicado: (2002)

Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release
por: Courtney, Kevin C., et al.
Publicado: (2021)

Autophagy inhibition in 3T3-L1 adipocytes breaks the crosstalk with tumor cells by suppression of adipokine production
por: Hwang, Sung-Hee, et al.
Publicado: (2019)

Influence of Macrocyclization on Allosteric, Juxtamembrane-Derived, Stapled Peptide Inhibitors of the Epidermal Growth Factor Receptor (EGFR)
por: Sinclair, Julie K.-L., et al.
Publicado: (2014)

SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells
por: Kim, Jeong Woo, et al.
Publicado: (2020)

Expression of E-cadherin, α-catenin, and β-catenin in the process of lymph node metastasis in oral squamous cell carcinoma
por: Tanaka, N, et al.
Publicado: (2003)

Competitive Regulation of E-Cadherin JuxtaMembrane Domain Degradation by p120-Catenin Binding and Hakai-Mediated Ubiquitination
por: Hartsock, Andrea, et al.
Publicado: (2012)

Electrical activity-triggered glucagon-like peptide-1 secretion from primary murine L-cells
por: Rogers, G J, et al.
Publicado: (2011)

Identification of epidermal growth factor receptor-derived peptides immunogenic for HLA-A2(+) cancer patients
por: Shomura, H, et al.
Publicado: (2004)

Super pharmacological levels of calcitriol (1,25-(OH)(2)D(3)) inhibits mineral deposition and decreases cell proliferation in a strain dependent manner in chicken mesenchymal stem cells undergoing osteogenic differentiation in vitro
por: Pande, Vivek V., et al.
Publicado: (2015)

The synaptotagmin juxtamembrane domain is involved in neuroexocytosis
por: Caccin, Paola, et al.
Publicado: (2015)

Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors
por: Qu, Haijun, et al.
Publicado: (2019)

A structurally derived model of subunit‐dependent NMDA receptor function
por: Gibb, Alasdair J., et al.
Publicado: (2018)

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex
por: Javadi, Arman, et al.
Publicado: (2017)

Data on the effects of N-cadherin perturbation on the expression of type II cadherin proteins and major signaling pathways
por: Rogers, Crystal D.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_uhg9ff30j8g6rjsgu95u9bbi98