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The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface
Mast cells are increasingly being recognized as crucial cells in the response of the organism to environmental agents. Interestingly, the ability of mast cells to sense and respond to external cues is modulated by the microenvironment that surrounds mast cells and influences their differentiation. T...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230381/ https://www.ncbi.nlm.nih.gov/pubmed/30510489 http://dx.doi.org/10.1155/2018/7396136 |
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author | Costantini, Claudio Renga, Giorgia Oikonomou, Vasilis Paolicelli, Giuseppe Borghi, Monica Pariano, Marilena De Luca, Antonella Puccetti, Matteo Stincardini, Claudia Mosci, Paolo Bartoli, Andrea Zelante, Teresa Romani, Luigina |
author_facet | Costantini, Claudio Renga, Giorgia Oikonomou, Vasilis Paolicelli, Giuseppe Borghi, Monica Pariano, Marilena De Luca, Antonella Puccetti, Matteo Stincardini, Claudia Mosci, Paolo Bartoli, Andrea Zelante, Teresa Romani, Luigina |
author_sort | Costantini, Claudio |
collection | PubMed |
description | Mast cells are increasingly being recognized as crucial cells in the response of the organism to environmental agents. Interestingly, the ability of mast cells to sense and respond to external cues is modulated by the microenvironment that surrounds mast cells and influences their differentiation. The scenario that is emerging unveils a delicate equilibrium that balances the effector functions of mast cells to guarantee host protection without compromising tissue homeostasis. Among the environmental components able to mold mast cells and fine-tune their effector functions, the microorganisms that colonize the human body, collectively known as microbiome, certainly play a key role. Indeed, microorganisms can regulate not only the survival, recruitment, and maturation of mast cells but also their activity by setting the threshold required for the exploitation of their different effector functions. Herein, we summarize the current knowledge about the mechanisms underlying the ability of the microorganisms to regulate mast cell physiology and discuss potential deviations that result in pathological consequences. We will discuss the pivotal role of the aryl hydrocarbon receptor in sensing the environment and shaping mast cell adaptation at the host-microbe interface. |
format | Online Article Text |
id | pubmed-6230381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-62303812018-12-03 The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface Costantini, Claudio Renga, Giorgia Oikonomou, Vasilis Paolicelli, Giuseppe Borghi, Monica Pariano, Marilena De Luca, Antonella Puccetti, Matteo Stincardini, Claudia Mosci, Paolo Bartoli, Andrea Zelante, Teresa Romani, Luigina Mediators Inflamm Review Article Mast cells are increasingly being recognized as crucial cells in the response of the organism to environmental agents. Interestingly, the ability of mast cells to sense and respond to external cues is modulated by the microenvironment that surrounds mast cells and influences their differentiation. The scenario that is emerging unveils a delicate equilibrium that balances the effector functions of mast cells to guarantee host protection without compromising tissue homeostasis. Among the environmental components able to mold mast cells and fine-tune their effector functions, the microorganisms that colonize the human body, collectively known as microbiome, certainly play a key role. Indeed, microorganisms can regulate not only the survival, recruitment, and maturation of mast cells but also their activity by setting the threshold required for the exploitation of their different effector functions. Herein, we summarize the current knowledge about the mechanisms underlying the ability of the microorganisms to regulate mast cell physiology and discuss potential deviations that result in pathological consequences. We will discuss the pivotal role of the aryl hydrocarbon receptor in sensing the environment and shaping mast cell adaptation at the host-microbe interface. Hindawi 2018-10-28 /pmc/articles/PMC6230381/ /pubmed/30510489 http://dx.doi.org/10.1155/2018/7396136 Text en Copyright © 2018 Claudio Costantini et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Costantini, Claudio Renga, Giorgia Oikonomou, Vasilis Paolicelli, Giuseppe Borghi, Monica Pariano, Marilena De Luca, Antonella Puccetti, Matteo Stincardini, Claudia Mosci, Paolo Bartoli, Andrea Zelante, Teresa Romani, Luigina The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
title | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
title_full | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
title_fullStr | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
title_full_unstemmed | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
title_short | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
title_sort | mast cell-aryl hydrocarbon receptor interplay at the host-microbe interface |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230381/ https://www.ncbi.nlm.nih.gov/pubmed/30510489 http://dx.doi.org/10.1155/2018/7396136 |
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