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Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus

BACKGROUND: Tinnitus is defined as a phantom auditory perception, i.e., sound experience despite the lack of acoustic stimuli in the environment. The aim of this study was to assess the state of the natural antioxidant barrier of a body in patients complaining about the presence of tinnitus. MATERIA...

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Autores principales: Pawlak-Osińska, Katarzyna, Kaźmierczak, Henryk, Marzec, Maria, Kupczyk, Daria, Bilski, Rafał, Mikołajewska, Emilia, Mikołajewski, Dariusz, Augustyńska, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230382/
https://www.ncbi.nlm.nih.gov/pubmed/30510615
http://dx.doi.org/10.1155/2018/1439575
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author Pawlak-Osińska, Katarzyna
Kaźmierczak, Henryk
Marzec, Maria
Kupczyk, Daria
Bilski, Rafał
Mikołajewska, Emilia
Mikołajewski, Dariusz
Augustyńska, Beata
author_facet Pawlak-Osińska, Katarzyna
Kaźmierczak, Henryk
Marzec, Maria
Kupczyk, Daria
Bilski, Rafał
Mikołajewska, Emilia
Mikołajewski, Dariusz
Augustyńska, Beata
author_sort Pawlak-Osińska, Katarzyna
collection PubMed
description BACKGROUND: Tinnitus is defined as a phantom auditory perception, i.e., sound experience despite the lack of acoustic stimuli in the environment. The aim of this study was to assess the state of the natural antioxidant barrier of a body in patients complaining about the presence of tinnitus. MATERIAL AND METHODS: The study included a total of 51 patients aged from 20 to 62 years with diagnosed idiopathic tinnitus and 19 healthy subjects as a control group. All patients underwent the audiometric tone test, speech audiometry, distortion otoacoustic emission product testing, study of evoked auditory potentials of short latency, and biochemical analysis of venous blood concerning values of activity or concentration of glutathione, glutathione peroxidase, S-transferase, glutathione reductase superoxide dismutase, malondialdehyde, and ceruloplasmin as the selected parameters of oxidative stress. RESULTS: Disorders of the auditory pathway were not only limited to the cochlea but also covered its further episodes. Mean values of activity or concentration of the selected parameters of oxidative stress in the study and control groups showed reduced effectiveness of the body's natural antioxidant barrier. DISCUSSION: Patients complaining about the presence of tinnitus showed reduced effectiveness of the body's natural antioxidant barrier compared to the control group. CONCLUSIONS: The main indication to undertake further research on the functioning of the antioxidant barrier in people suffering from ailments in the form of tinnitus is to determine a suitable therapy aimed at improving the quality of life of these patients, which might be the administration of antioxidant medications.
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spelling pubmed-62303822018-12-03 Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus Pawlak-Osińska, Katarzyna Kaźmierczak, Henryk Marzec, Maria Kupczyk, Daria Bilski, Rafał Mikołajewska, Emilia Mikołajewski, Dariusz Augustyńska, Beata Oxid Med Cell Longev Research Article BACKGROUND: Tinnitus is defined as a phantom auditory perception, i.e., sound experience despite the lack of acoustic stimuli in the environment. The aim of this study was to assess the state of the natural antioxidant barrier of a body in patients complaining about the presence of tinnitus. MATERIAL AND METHODS: The study included a total of 51 patients aged from 20 to 62 years with diagnosed idiopathic tinnitus and 19 healthy subjects as a control group. All patients underwent the audiometric tone test, speech audiometry, distortion otoacoustic emission product testing, study of evoked auditory potentials of short latency, and biochemical analysis of venous blood concerning values of activity or concentration of glutathione, glutathione peroxidase, S-transferase, glutathione reductase superoxide dismutase, malondialdehyde, and ceruloplasmin as the selected parameters of oxidative stress. RESULTS: Disorders of the auditory pathway were not only limited to the cochlea but also covered its further episodes. Mean values of activity or concentration of the selected parameters of oxidative stress in the study and control groups showed reduced effectiveness of the body's natural antioxidant barrier. DISCUSSION: Patients complaining about the presence of tinnitus showed reduced effectiveness of the body's natural antioxidant barrier compared to the control group. CONCLUSIONS: The main indication to undertake further research on the functioning of the antioxidant barrier in people suffering from ailments in the form of tinnitus is to determine a suitable therapy aimed at improving the quality of life of these patients, which might be the administration of antioxidant medications. Hindawi 2018-10-28 /pmc/articles/PMC6230382/ /pubmed/30510615 http://dx.doi.org/10.1155/2018/1439575 Text en Copyright © 2018 Katarzyna Pawlak-Osińska et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pawlak-Osińska, Katarzyna
Kaźmierczak, Henryk
Marzec, Maria
Kupczyk, Daria
Bilski, Rafał
Mikołajewska, Emilia
Mikołajewski, Dariusz
Augustyńska, Beata
Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus
title Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus
title_full Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus
title_fullStr Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus
title_full_unstemmed Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus
title_short Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus
title_sort assessment of the state of the natural antioxidant barrier of a body in patients complaining about the presence of tinnitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230382/
https://www.ncbi.nlm.nih.gov/pubmed/30510615
http://dx.doi.org/10.1155/2018/1439575
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