Cargando…

Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation

Autonomic control of blood pressure (BP) and heart rate (HR) is crucial during bleeding and hemorrhagic shock (HS) to compensate for hypotension and hypoxia. Previous works have observed that at the point of hemodynamic decompensation a marked suppression of BP and HR variability occurs, leading to...

Descripción completa

Detalles Bibliográficos
Autores principales: Carrara, Marta, Babini, Giovanni, Baselli, Giuseppe, Ristagno, Giuseppe, Pastorelli, Roberta, Brunelli, Laura, Ferrario, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230573/
https://www.ncbi.nlm.nih.gov/pubmed/30001154
http://dx.doi.org/10.1152/japplphysiol.00348.2018
_version_ 1783370100339900416
author Carrara, Marta
Babini, Giovanni
Baselli, Giuseppe
Ristagno, Giuseppe
Pastorelli, Roberta
Brunelli, Laura
Ferrario, Manuela
author_facet Carrara, Marta
Babini, Giovanni
Baselli, Giuseppe
Ristagno, Giuseppe
Pastorelli, Roberta
Brunelli, Laura
Ferrario, Manuela
author_sort Carrara, Marta
collection PubMed
description Autonomic control of blood pressure (BP) and heart rate (HR) is crucial during bleeding and hemorrhagic shock (HS) to compensate for hypotension and hypoxia. Previous works have observed that at the point of hemodynamic decompensation a marked suppression of BP and HR variability occurs, leading to irreversible shock. We hypothesized that recovery of the autonomic control may be decisive for effective resuscitation, along with restoration of mean BP. We computed cardiovascular indexes of baroreflex sensitivity and BP and HR variability by analyzing hemodynamic recordings collected from five pigs during a protocol of severe hemorrhage and resuscitation; three pigs were sham-treated controls. Moreover, we assessed the effects of severe hemorrhage on heart functionality by integrating the hemodynamic findings with measures of plasma high-sensitivity cardiac troponin T and metabolite concentrations in left ventricular (LV) tissue. Resuscitation was performed with fluids and norepinephrine and then by reinfusion of shed blood. After first resuscitation, mean BP reached the target value, but cardiovascular indexes were not fully restored, hinting at a partial recovery of the autonomic mechanisms. Moreover, cardiac troponins were still elevated, suggesting a persistent myocardial sufferance. After blood reinfusion all the indexes returned to baseline. In the harvested heart, LV metabolic profile confirmed the acute stress condition sensed by the cardiomyocytes. Variability indexes and baroreflex trends can be valuable tools to evaluate the severity of HS, and they may represent a more useful end point for resuscitation in combination with standard measures such as mean values and biological measures. NEW & NOTEWORTHY Autonomic control of blood pressure was highly impaired during hemorrhagic shock, and it was not completely recovered after resuscitation despite global restoration of mean pressures. Moreover, a persistent myocardial sufferance emerged from measured cardiac troponin T and metabolite concentrations of left ventricular tissue. We highlight the importance of combining global mean values and biological markers with measures of variability and autonomic control for a better characterization of the effectiveness of the resuscitation strategy.
format Online
Article
Text
id pubmed-6230573
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Physiological Society
record_format MEDLINE/PubMed
spelling pubmed-62305732018-11-13 Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation Carrara, Marta Babini, Giovanni Baselli, Giuseppe Ristagno, Giuseppe Pastorelli, Roberta Brunelli, Laura Ferrario, Manuela J Appl Physiol (1985) Research Article Autonomic control of blood pressure (BP) and heart rate (HR) is crucial during bleeding and hemorrhagic shock (HS) to compensate for hypotension and hypoxia. Previous works have observed that at the point of hemodynamic decompensation a marked suppression of BP and HR variability occurs, leading to irreversible shock. We hypothesized that recovery of the autonomic control may be decisive for effective resuscitation, along with restoration of mean BP. We computed cardiovascular indexes of baroreflex sensitivity and BP and HR variability by analyzing hemodynamic recordings collected from five pigs during a protocol of severe hemorrhage and resuscitation; three pigs were sham-treated controls. Moreover, we assessed the effects of severe hemorrhage on heart functionality by integrating the hemodynamic findings with measures of plasma high-sensitivity cardiac troponin T and metabolite concentrations in left ventricular (LV) tissue. Resuscitation was performed with fluids and norepinephrine and then by reinfusion of shed blood. After first resuscitation, mean BP reached the target value, but cardiovascular indexes were not fully restored, hinting at a partial recovery of the autonomic mechanisms. Moreover, cardiac troponins were still elevated, suggesting a persistent myocardial sufferance. After blood reinfusion all the indexes returned to baseline. In the harvested heart, LV metabolic profile confirmed the acute stress condition sensed by the cardiomyocytes. Variability indexes and baroreflex trends can be valuable tools to evaluate the severity of HS, and they may represent a more useful end point for resuscitation in combination with standard measures such as mean values and biological measures. NEW & NOTEWORTHY Autonomic control of blood pressure was highly impaired during hemorrhagic shock, and it was not completely recovered after resuscitation despite global restoration of mean pressures. Moreover, a persistent myocardial sufferance emerged from measured cardiac troponin T and metabolite concentrations of left ventricular tissue. We highlight the importance of combining global mean values and biological markers with measures of variability and autonomic control for a better characterization of the effectiveness of the resuscitation strategy. American Physiological Society 2018-10-01 2018-07-12 /pmc/articles/PMC6230573/ /pubmed/30001154 http://dx.doi.org/10.1152/japplphysiol.00348.2018 Text en Copyright © 2018 the American Physiological Society http://creativecommons.org/licenses/by/3.0/deed.en_US Licensed under Creative Commons Attribution CC-BY 4.0 (http://creativecommons.org/licenses/by/3.0/deed.en_US) : © the American Physiological Society.
spellingShingle Research Article
Carrara, Marta
Babini, Giovanni
Baselli, Giuseppe
Ristagno, Giuseppe
Pastorelli, Roberta
Brunelli, Laura
Ferrario, Manuela
Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation
title Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation
title_full Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation
title_fullStr Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation
title_full_unstemmed Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation
title_short Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation
title_sort blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230573/
https://www.ncbi.nlm.nih.gov/pubmed/30001154
http://dx.doi.org/10.1152/japplphysiol.00348.2018
work_keys_str_mv AT carraramarta bloodpressurevariabilityheartfunctionalityandleftventriculartissuealterationsinaprotocolofseverehemorrhagicshockandresuscitation
AT babinigiovanni bloodpressurevariabilityheartfunctionalityandleftventriculartissuealterationsinaprotocolofseverehemorrhagicshockandresuscitation
AT baselligiuseppe bloodpressurevariabilityheartfunctionalityandleftventriculartissuealterationsinaprotocolofseverehemorrhagicshockandresuscitation
AT ristagnogiuseppe bloodpressurevariabilityheartfunctionalityandleftventriculartissuealterationsinaprotocolofseverehemorrhagicshockandresuscitation
AT pastorelliroberta bloodpressurevariabilityheartfunctionalityandleftventriculartissuealterationsinaprotocolofseverehemorrhagicshockandresuscitation
AT brunellilaura bloodpressurevariabilityheartfunctionalityandleftventriculartissuealterationsinaprotocolofseverehemorrhagicshockandresuscitation
AT ferrariomanuela bloodpressurevariabilityheartfunctionalityandleftventriculartissuealterationsinaprotocolofseverehemorrhagicshockandresuscitation