The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation

Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an essential function in cell survival and is highly expressed in many cancers. Inhibition of TRPM2 in neuroblastoma by depletion with CRISPR technology or expression of dominant negative TRPM2-S has been shown to signifi...

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Detalles Bibliográficos
Autores principales: Hirschler-Laszkiewicz, Iwona, Chen, Shu-jen, Bao, Lei, Wang, JuFang, Zhang, Xue-Qian, Shanmughapriya, Santhanam, Keefer, Kerry, Madesh, Muniswamy, Cheung, Joseph Y., Miller, Barbara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230687/
https://www.ncbi.nlm.nih.gov/pubmed/30020827
http://dx.doi.org/10.1152/ajpcell.00098.2018

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