Experience-related reductions of myelin and axon diameter in adulthood

The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, Heß M, Grothe B, Leibold C, an...

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Detalles Bibliográficos
Autores principales: Lazari, Alberto, Koudelka, Sigrid, Sampaio-Baptista, Cassandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2018
Materias:
Neuro Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230794/
https://www.ncbi.nlm.nih.gov/pubmed/30207857
http://dx.doi.org/10.1152/jn.00070.2018
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author Lazari, Alberto
Koudelka, Sigrid
Sampaio-Baptista, Cassandra
author_facet Lazari, Alberto
Koudelka, Sigrid
Sampaio-Baptista, Cassandra
author_sort Lazari, Alberto
collection PubMed
description The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, Heß M, Grothe B, Leibold C, and Kopp-Scheinpflug C. J Neurosci 37: 8239–8255, 2017) have shown that auditory deprivation can lead to decrease in myelination and axon caliber even in healthy adulthood. These findings show that activity-regulated myelination is more complex than previously thought and expand our knowledge of how adult brain plasticity could operate on a cellular level.
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spelling pubmed-62307942018-11-13 Experience-related reductions of myelin and axon diameter in adulthood Lazari, Alberto Koudelka, Sigrid Sampaio-Baptista, Cassandra J Neurophysiol Neuro Forum The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, Heß M, Grothe B, Leibold C, and Kopp-Scheinpflug C. J Neurosci 37: 8239–8255, 2017) have shown that auditory deprivation can lead to decrease in myelination and axon caliber even in healthy adulthood. These findings show that activity-regulated myelination is more complex than previously thought and expand our knowledge of how adult brain plasticity could operate on a cellular level. American Physiological Society 2018-10-01 2018-09-12 /pmc/articles/PMC6230794/ /pubmed/30207857 http://dx.doi.org/10.1152/jn.00070.2018 Text en Copyright © 2018 the American Physiological Society http://creativecommons.org/licenses/by/4.0/deed.en_US Licensed under Creative Commons Attribution CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/deed.en_US) : © the American Physiological Society.
spellingShingle Neuro Forum
Lazari, Alberto
Koudelka, Sigrid
Sampaio-Baptista, Cassandra
Experience-related reductions of myelin and axon diameter in adulthood
title Experience-related reductions of myelin and axon diameter in adulthood
title_full Experience-related reductions of myelin and axon diameter in adulthood
title_fullStr Experience-related reductions of myelin and axon diameter in adulthood
title_full_unstemmed Experience-related reductions of myelin and axon diameter in adulthood
title_short Experience-related reductions of myelin and axon diameter in adulthood
title_sort experience-related reductions of myelin and axon diameter in adulthood
topic Neuro Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230794/
https://www.ncbi.nlm.nih.gov/pubmed/30207857
http://dx.doi.org/10.1152/jn.00070.2018
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