Cellular density‐dependent increases in HIF‐1α compete with c‐Myc to down‐regulate human EP4 receptor promoter activity through Sp‐1‐binding region

The up‐regulated expression of E‐type prostanoid (EP) 4 receptors has been implicated in carcinogenesis; however, the expression of EP4 receptors has also been reported to be weaker in tumor tissues than in normal tissues. Indeed, EP4 receptors have been suggested to play a role in the maintenance o...

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Detalles Bibliográficos
Autores principales: Seira, Naofumi, Yamagata, Kazuyuki, Fukushima, Keijo, Araki, Yumi, Kurata, Naoki, Yanagisawa, Naoki, Mashimo, Masato, Nakamura, Hiroyuki, Regan, John W., Murayama, Toshihiko, Fujino, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230926/
https://www.ncbi.nlm.nih.gov/pubmed/30455960
http://dx.doi.org/10.1002/prp2.441

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